{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:35:29Z","timestamp":1786977329715,"version":"build-2736575974"},"reference-count":18,"publisher":"Wiley","issue":"5","license":[{"start":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T00:00:00Z","timestamp":1710547200000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,3]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Blinatumomab early\u2010line treatment in B\u2010cell precursor acute lymphoblastic leukemia (B\u2010ALL) might improve clinical outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective real\u2010world cohort analysis in 20 newly diagnosed B\u2010ALL patients who received reduced\u2010dose chemotherapy (idarubicin, vindesine, and dexamethasone) for 1\u20133\u2009weeks, followed by blinatumomab for 1\u20134\u2009weeks as an induction therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      At the end of the induction therapy, a complete remission rate of 100% was achieved; 17 (85%) patients were minimal residual disease (MRD) negative (&lt;1\u2009\u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      ). Adverse events (AEs) were reported in 12 (60%) patients\u201443.8% were grade 1\u20132 and 56.2% were grade 3\u20134. No incidence of neurotoxicity or grade\u2009\u22653 cytokine release syndrome was reported.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Blinatumomab demonstrated a significant improvement in clinical outcomes in patients with newly diagnosed B\u2010ALL irrespective of their poor\u2010risk factor status and the pretreatment blast burden.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.7062","type":"journal-article","created":{"date-parts":[[2024,3,16]],"date-time":"2024-03-16T03:54:45Z","timestamp":1710561285000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Reduced\u2010dose chemotherapy followed by blinatumomab in induction therapy for newly diagnosed B\u2010cell acute lymphoblastic leukemia"],"prefix":"10.1002","volume":"13","author":[{"given":"Jing","family":"Lu","sequence":"first","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huifen","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Zhou","sequence":"additional","affiliation":[{"name":"Department of Hematology Wuxi People's Hospital Affiliated to Nanjing Medical University  WuXi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yonggong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Affiliated Drum Tower Hospital of Nanjing University Medical School  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laigen","family":"Tong","sequence":"additional","affiliation":[{"name":"Yixing People's Hospital, The Affiliated Hospital of Jiangsu University  Yixing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3435-9498","authenticated-orcid":false,"given":"Miao","family":"Miao","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9847-5009","authenticated-orcid":false,"given":"Xiaofei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases  Suzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2967-3597","authenticated-orcid":false,"given":"Suning","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology The First Affiliated Hospital of Soochow University, Jiangsu Institute of Hematology, National Clinical Research Center for Hematologic Diseases  Suzhou 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