{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,24]],"date-time":"2026-07-24T18:25:50Z","timestamp":1784917550457,"version":"3.55.0"},"reference-count":24,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T00:00:00Z","timestamp":1738886400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chronic myeloid leukemia (CML) is a hematologic malignancy characterized by the translocation t(9;22)(q34;q11.2), which results in a constitutively active tyrosine kinase. The introduction of tyrosine kinase inhibitors (TKIs) has significantly altered the disease course for patients with BCR\u2010ABL1+ CML globally.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This study aimed to evaluate the treatment outcomes of CML patients in Ethiopia.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methodology<\/jats:title><jats:p>This was a single\u2010center, cross\u2010sectional study conducted on 330 patients diagnosed with CML, who were on TKI therapy and receiving follow\u2010up at Tikur Anbessa Specialized Hospital (TASH). Data were collected from electronic medical records using a structured data abstraction tool. Chi\u2010square statistics and binary logistic regression were employed to examine the associations between categorical variables, with statistical significance set at a <jats:italic>p<\/jats:italic> value &lt;\u20090.05. A 95% confidence interval was used.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The median age of patients was 37.0\u2009years (interquartile range [IQR]: 29.0\u201349.3), and 185 (56.1%) of the patients were male. At diagnosis, 92.1% were in the chronic phase of CML, while 9 (2.7%) were in blast crisis. The complete hematologic response (CHR) rate at 3\u2009months was 90.9% (291\/320), while the CHR rate beyond 3\u2009months was 90.2% (258\/286). Multivariable logistic regression analysis showed that the likelihood of not achieving a complete\/partial hematologic response was higher among those diagnosed in the advanced phase of CML (AOR: 6.114, 95% CI: 2.210, 16.910) and among patients requiring a treatment change (AOR: 5.765, 95% CI: 2.460, 13.512).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The median age of CML patients in our study was notably young. The 3\u2010month and overall hematologic responses were excellent. The initial phase of CML at diagnosis and treatment switch was associated with the 3\u2010month CHR, while only treatment switch was associated with the overall CHR.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70635","type":"journal-article","created":{"date-parts":[[2025,2,7]],"date-time":"2025-02-07T13:03:56Z","timestamp":1738933436000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Assessment of Treatment Outcome in Chronic Myelogenous Leukemia Patients on Tyrosine Kinase Inhibitors: Insight From a Resource Limited Setting"],"prefix":"10.1002","volume":"14","author":[{"given":"Wude Yewondwosen","family":"Awlachew","sequence":"first","affiliation":[{"name":"Department of Internal Medicine Addis Ababa University  Addis Ababa Ethiopia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-6923-1753","authenticated-orcid":false,"given":"Abel 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