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The primary endpoint was overall survival (OS).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 110 patients were enrolled. The majority of patients were male (81%), with a median age of 65\u2009years (range, 36\u201384). The median OS was not reached, with a 1\u2010year OS rate of 78.7%. The median PFS was 9.5\u2009months (95% CI, 7.8\u201311.2\u2009months). The ORR to first\u2010line chemotherapy was 48.2%, and an additional 34.6% of patients responded to avelumab therapy (16 complete and 22 partial responses). Grade 3 adverse events during avelumab therapy were experienced by 11.8% of patients.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>These findings demonstrate similar efficacy and safety of avelumab in a real\u2010world setting when compared to data from pivotal study.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> KCRB registry number: RAVE\u2010Bladder<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70636","type":"journal-article","created":{"date-parts":[[2025,2,14]],"date-time":"2025-02-14T09:45:01Z","timestamp":1739526301000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Maintenance Therapy With Avelumab for Patients With Metastatic Urothelial Carcinoma: A Real\u2010World, Ambispective <scp>RAVE<\/scp>\u2010Bladder Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7357-0392","authenticated-orcid":false,"given":"Ilya","family":"Tsimafeyeu","sequence":"first","affiliation":[{"name":"Bureau of Cancer Research\u2014Moscow Office  Moscow Russian Federation"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yana","family":"Gridneva","sequence":"additional","affiliation":[{"name":"Oncological Center No.1 of Moscow City Hospital Named After S.S. 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