{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,24]],"date-time":"2026-09-24T11:16:19Z","timestamp":1790248579027,"version":"4.1.0"},"reference-count":51,"publisher":"Wiley","issue":"3","license":[{"start":{"date-parts":[[2025,2,10]],"date-time":"2025-02-10T00:00:00Z","timestamp":1739145600000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007605","name":"Aarhus Universitet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007605","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006197","name":"Fonden til L\u00e6gevidenskabens Fremme","doi-asserted-by":"publisher","award":["L\u20102021\u201000257"],"award-info":[{"award-number":["L\u20102021\u201000257"]}],"id":[{"id":"10.13039\/501100006197","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Acute kidney injury (AKI) can be a severe complication in cancer patients. However, uncertainty remains regarding the risk of and prognosis after AKI following cancer treatments. We therefore aimed to examine the risk of and mortality after AKI following a wide range of specific cancer treatments, including surgical procedures, anticancer drugs, and hematopoietic stem cell transplantations (HSCTs).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a nationwide population\u2010based cohort study. We included adult patients receiving cancer treatment in Denmark from 2010 to 2024. We calculated the risk of AKI within 7\u2009days after surgeries, 1\u2009year after initiation of anticancer drugs, and 100\u2009days after HSCTs. Furthermore, we examined the 1\u2010year mortality in patients with and without AKI following cancer treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We identified 357,870 cancer patients. The 7\u2010day risk of AKI after surgery ranged from 0.3% (breast cancer surgery) to 68.9% (radical nephrectomy in kidney cancer) while the 1\u2010year risk following anticancer drug treatment ranged from 3.5% (cyclophosphamide in breast cancer) to 79.3% (all drugs in acute lymphatic leukemia). The 100\u2010day AKI risk following HSCT ranged from 20.7% (multiple myeloma) to 81.8% (leukemia). For most treatments, AKI was associated with a higher 1\u2010year hazard ratio and risk of death, with exceptions including radical nephrectomy in kidney cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In conclusion, several cancer treatments were associated with a high risk of AKI, and AKI was associated with increased mortality in most treatments. These findings highlight the prognostic value of assessing kidney function following specific cancer treatments in clinical practice.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70646","type":"journal-article","created":{"date-parts":[[2025,2,11]],"date-time":"2025-02-11T04:50:30Z","timestamp":1739249430000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Risk of and Mortality After Acute Kidney Injury Following Cancer Treatment: A Cohort Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8239-2970","authenticated-orcid":false,"given":"Philip Vestergaard","family":"Munch","sequence":"first","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus 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Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Renal Medicine Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Biomedicine Aarhus University  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4063-3561","authenticated-orcid":false,"given":"Henrik","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Clinical Medicine Aarhus University  Aarhus Denmark"},{"name":"Department of Oncology Aarhus University Hospital  Aarhus Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0727-953X","authenticated-orcid":false,"given":"Christian Fynbo","family":"Christiansen","sequence":"additional","affiliation":[{"name":"Department of Clinical Epidemiology Aarhus University Hospital  Aarhus Denmark"},{"name":"Department of Clinical Medicine Aarhus University  Aarhus 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