{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T04:30:11Z","timestamp":1789705811302,"version":"4.0.1"},"reference-count":25,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T00:00:00Z","timestamp":1745280000000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Prior research has identified temporal muscle thickness (TMT) as a prognostic marker in glioblastoma. Nonetheless, implementation in daily clinical practice is complicated due to the heterogeneity of previous studies. We performed a multicentric analysis aiming to validate recently proposed sex\u2010specific cutoff values using a homogeneous cohort of newly diagnosed <jats:italic>MGMT<\/jats:italic> promoter methylated glioblastoma patients; we included a balanced control cohort for comparison.<\/jats:p><\/jats:sec><jats:sec><jats:title>Materials and Methods<\/jats:title><jats:p>TMT was measured at baseline using the initial preoperative\/postoperative magnetic resonance images (MRIs) and in disease course using the first MRI after radiotherapy. Patients were divided by sex and TMT into \u201cat risk of sarcopenia\u201d or \u201cnormal muscle status.\u201d Kaplan\u2013Meier and multivariable Cox regression analysis was used for survival correlation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>In total, <jats:italic>n<\/jats:italic>\u2009=\u2009126 patients were included (<jats:italic>n<\/jats:italic>\u2009=\u200966 treated with CCNU\/temozolomide, <jats:italic>n<\/jats:italic>\u2009=\u200960 with single\u2010drug temozolomide). Patients with normal muscle mass at baseline had significantly prolonged survival (median overall survival: 44.2\u2009months versus 16.7\u2009months with CCNU\/temozolomide, and 29.5\u2009months versus 17.4\u2009months with single\u2010drug temozolomide) compared to those at risk of sarcopenia. In a multivariable Cox regression analysis, normal muscle mass and an initial age at diagnosis of &lt;\u200950\u2009years emerged as significant prognostic markers. Longitudinally, survival was longest in patients with lack of TMT decline over the disease course.<\/jats:p><\/jats:sec><jats:sec><jats:title>Discussion<\/jats:title><jats:p>This analysis confirms TMT as an important prognostic marker in glioblastoma in two real\u2010life cohorts. However, in order to establish TMT assessment as a routine marker for patient selection and therapeutic measures, further validation in prospective controlled trials is necessary.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70689","type":"journal-article","created":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T09:19:35Z","timestamp":1745313575000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Temporal Muscle Thickness as a Prognostic Marker in a Real\u2010Life Cohort of Newly Diagnosed <i>MGMT<\/i> Promoter Methylated Glioblastoma: A Multicentric Imaging Analysis"],"prefix":"10.1002","volume":"14","author":[{"given":"Lazaros","family":"Lazaridis","sequence":"first","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Moenninghoff","sequence":"additional","affiliation":[{"name":"University Institute for Radiology, Neuroradiology and Nuclear Medicine Johannes Wesling Klinikum Minden  Minden Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elisabeth","family":"Bumes","sequence":"additional","affiliation":[{"name":"Department of Neurology and Wilhelm Sander\u2010NeuroOncology Unit University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothee C\u00e4cilia","family":"Spille","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"M\u00fcther","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tim","family":"Schulz","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sina","family":"Heider","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarina","family":"Agkatsev","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Neurology, University Hospital Knappschaftskrankenhaus Bochum Ruhr University Bochum  Bochum Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tobias","family":"Blau","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Institute of Neuropathology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"DKFZ Division Translational Neurooncology at the WTZ and German Cancer Consortium (DKTK) Partner site Essen\/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Oster","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"DKFZ Division Translational Neurooncology at the WTZ and German Cancer Consortium (DKTK) Partner site Essen\/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walter","family":"Stummer","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital M\u00fcnster  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Almuth Friederike","family":"Kessler","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery University Hospital of W\u00fcrzburg  W\u00fcrzburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clemens","family":"Seidel","sequence":"additional","affiliation":[{"name":"Department of Radiotherapy and Radiation Oncology University Hospital Leipzig  Leipzig Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oliver","family":"Grauer","sequence":"additional","affiliation":[{"name":"Department of Neurology with Institute of Translational Neurology  M\u00fcnster Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3894-5053","authenticated-orcid":false,"given":"Peter","family":"Hau","sequence":"additional","affiliation":[{"name":"Department of Neurology and Wilhelm Sander\u2010NeuroOncology Unit University Hospital Regensburg  Regensburg Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yahya","family":"Ahmadipour","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Neurosurgery and Spine Surgery University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Sure","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Neurosurgery and Spine Surgery University Medicine Essen, University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathy","family":"Keyvani","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Institute of Neuropathology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Herrlinger","sequence":"additional","affiliation":[{"name":"Division of Clinical Neurooncology, Department of Neurology and Center for Integrated Oncology University Hospital Bonn  Bonn Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christoph","family":"Kleinschnitz","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Stuschke","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Radiotherapy University Medicine Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nika","family":"Guberina","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Radiotherapy University Medicine Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Herrmann","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Department of Nuclear Medicine, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cornelius","family":"Deuschl","sequence":"additional","affiliation":[{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"Institute for Diagnostic and Interventional Radiology and Neuroradiology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bj\u00f6rn","family":"Scheffler","sequence":"additional","affiliation":[{"name":"DKFZ Division Translational Neurooncology at the WTZ and German Cancer Consortium (DKTK) Partner site Essen\/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sied","family":"Kebir","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"DKFZ Division Translational Neurooncology at the WTZ and German Cancer Consortium (DKTK) Partner site Essen\/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen  Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3167-3403","authenticated-orcid":false,"given":"Martin","family":"Glas","sequence":"additional","affiliation":[{"name":"Department of Neurology and Center for Translational Neuro\u2010 and Behavioral Sciences (C\u2010TNBS), Division of Clinical Neurooncology, University Medicine Essen University Duisburg\u2010Essen  Essen Germany"},{"name":"German Cancer Consortium (DKTK) Partner Site University Medicine Essen  Essen Germany"},{"name":"DKFZ Division Translational Neurooncology at the WTZ and German Cancer Consortium (DKTK) Partner site Essen\/D\u00fcsseldorf, a partnership between DKFZ and University Hospital Essen  Germany"},{"name":"Division of Clinical Neurooncology, Department of Neurology and Center for Integrated Oncology University Hospital Bonn  Bonn Germany"},{"name":"Department of Neurology and Neurooncology St. Marien Hospital L\u00fcnen  L\u00fcnen Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,22]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noaa106"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2020.1024"},{"key":"e_1_2_10_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140\u20106736(18)31791\u20104"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdac137"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(07)70384\u20104"},{"key":"e_1_2_10_7_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0207849"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noz131"},{"key":"e_1_2_10_9_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00432\u2010020\u201003386\u20105"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clineuro.2021.106782"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fneur.2020.523292"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010020\u201007471\u20108"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/CMAR.S326232"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/ajco.13369"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078\u20100432.CCR\u201021\u20101987"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1093\/noajnl\/vdac038"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10143\u2010022\u201001892\u20103"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416\u2010021\u201001590\u20109"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1093\/ageing\/afy169"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(14)70379\u20101"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/nou356"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa043330"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2009.26.3541"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13311\u2010016\u20100507\u20106"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/oncsis.2016.3"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.wneu.2022.02.038"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70689","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:11:42Z","timestamp":1745493102000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70689"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":25,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/cam4.70689"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70689","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2024-05-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-02-04","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-22","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70689"}}