{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T21:19:01Z","timestamp":1775078341240,"version":"3.50.1"},"reference-count":42,"publisher":"Wiley","issue":"4","license":[{"start":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T00:00:00Z","timestamp":1739577600000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000098","name":"Clinical Center","doi-asserted-by":"publisher","award":["1ZIABC011768\u201003"],"award-info":[{"award-number":["1ZIABC011768\u201003"]}],"id":[{"id":"10.13039\/100000098","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,2]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Introduction<\/jats:title><jats:p>Sleep disturbance (SD) and sleep\u2010related impairment (SRI) significantly impact the lives of primary brain tumor (PBT) patients. We aimed to describe the prevalence of SD and SRI in this population, determine the reliability of the PROMIS\u2010SD and PROMIS\u2010SRI instruments, and identify predictive factors to support the development of targeted interventions for at\u2010risk individuals.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>This cross\u2010sectional study evaluated SD and SRI in PBT patients enrolled in a Natural History Study who completed 1\u2010year follow\u2010up questionnaires (<jats:italic>N<\/jats:italic>\u2009=\u2009229). Demographic, clinical, and socioeconomic data were analyzed to identify factors associated with SD and SRI. Descriptive statistics were used to report the prevalence of sleep problems, and linear regression analysis was conducted to identify predictive factors. The reliability of sleep\u2010related instruments was calculated using Cronbach's alpha.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifteen percent of PBT participants reported clinically significant SD and 20% reported clinically significant SRI, which were associated with financial toxicity (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), being unemployed (<jats:italic>p\u2009\u2264<\/jats:italic>\u20090.02), and taking psychotropic medication (<jats:italic>p\u2009\u2264\u20090.<\/jats:italic>002). Good internal consistency was demonstrated by the SD (0.923) and SRI (0.925) questionnaires in this population.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>In this study, social factors such as financial toxicity and employment status were associated with SD and SRI. Psychotropic medications also impacted SD and SRI in PTB survivors, but less so than financial toxicity. Social factors and other medications may impact sleep more strongly in PBT survivors than their previous treatment courses.<\/jats:p><\/jats:sec><jats:sec><jats:title>Implications for Cancer Survivors<\/jats:title><jats:p>SD and SRI can be impacted by multiple factors, including those not related to PBT treatment, which should be considered by their providers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70693","type":"journal-article","created":{"date-parts":[[2025,2,15]],"date-time":"2025-02-15T08:15:02Z","timestamp":1739607302000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Social Determinants of Health Predict Sleep\u2013Wake Disturbances Among Patients Living With Primary Brain Tumors: A Cross\u2010Sectional Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9348-8740","authenticated-orcid":false,"given":"Michelle 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