{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T14:46:50Z","timestamp":1787928410644,"version":"build-2784847793"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001009","name":"Bristol Myers Squibb Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001009","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>Dual checkpoint inhibitor therapy with nivolumab and ipilimumab has been FDA approved for a number of cancer sites. However, its role in the treatment of ACC and non\u2010ACC salivary gland carcinomas (non\u2010ACC SGC) is not well established.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods and Analysis<\/jats:title><jats:p>We performed Simon's two\u2010stage prospective single\u2010institution Phase II clinical trial of nivolumab with ipilimumab. Two cohorts were analyzed: patients with metastatic\/recurrent ACC and patients with non\u2010ACC SGC. The primary endpoint was median progression\u2010free survival (PFS); secondary endpoints were overall response rate (ORR), overall survival (OS), and toxicity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Patient enrollment was prematurely terminated due to funding constraints. In total, 19 patients with ACC and 5 patients with non\u2010ACC SGC were enrolled. The patients with ACC had a median OS of 30.0\u2009months (95% CI 15.3\u2010NR months), a median PFS of 8.3\u2009months (95% CI 5.5\u201330.0\u2009months), and a disease control rate (DCR) of 53% (10\/19). The ORR in the ACC group was 5% (CR 0%, <jats:italic>n<\/jats:italic>\u2009=\u20090; confirmed PR 5%, <jats:italic>n<\/jats:italic>\u2009=\u20091), with one patient having continued stable disease at the time of trial conclusion. The patients with non\u2010ACC SGC had a median OS of 10.4\u2009months (95% CI 6.21\u2010NR months), a median PFS of 6.21\u2009months (95% CI 2.83\u2010NR months), and a DCR of 40% (2\/5). The ORR in this cohort was 0%.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>In patients with recurrent or metastatic ACC and non\u2010ACC SGC, the combination of nivolumab with ipilimumab resulted in moderate disease control. Further studies are warranted to validate our findings.<\/jats:p><jats:p>Trial number: NCT03146650.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70724","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T10:03:32Z","timestamp":1743588212000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Phase <scp>II<\/scp> Study of Nivolumab and Ipilimumab for Treatment of Metastatic\/Recurrent Adenoid Cystic Carcinoma (<scp>ACC<\/scp>) of all Anatomic Sites of Origin and Other Malignant Salivary Gland Tumors"],"prefix":"10.1002","volume":"14","author":[{"given":"Young Kwang","family":"Chae","sequence":"first","affiliation":[{"name":"Department of Hematology and Oncology Northwestern University  Chicago Illinois USA"},{"name":"Feinberg School of Medicine Northwestern University  Chicago Illinois 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