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In recent years, mature B cell antigen\u2010targeting therapy has brought new hope for patients with refractory\/relapsed disease. While an increasing number of patients with relapse are exposed to this type of drug, changing the therapeutic target may be an effective strategy for patients with relapse\/refractory multiple myeloma.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>The expression of G protein\u2010coupled receptor, class C Group 5 member D (GPRC5D), on the surface of myeloma tumor cells makes it a possible target for relapse\/refractory multiple myeloma therapy, and relevant studies are in progress.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Conclusions<\/jats:title><jats:p>The review aims to systematically summarize the current advancements in GPRC5D\u2010targeted therapies for multiple myeloma, thereby providing valuable insights and a foundation for future 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