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Prior studies demonstrated higher inflammation in people from high deprivation areas. The area deprivation index (ADI) is a composite measure of income, education, employment, and housing, which quantifies neighborhood deprivation. We used the <jats:italic>All of Us<\/jats:italic> dataset to test whether inflammation, measured via c\u2010reactive protein (CRP), albumin, and the neutrophil\u2010to\u2010lymphocyte ratio (NLR), differs by ADI in cancer survivors.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Our sample included individuals with a history of lung, breast, prostate, and colorectal cancer, filtered for the presence of the inflammatory biomarkers. We used quartiles of ADI based on 3\u2010digit zip code and biomarkers from electronic health records. We estimated the association between ADI and inflammation using adjusted logistic regression (<jats:italic>n<\/jats:italic>\u2009=\u2009690 for CRP; <jats:italic>n<\/jats:italic>\u2009=\u20094242 for albumin; <jats:italic>n<\/jats:italic>\u2009=\u20095183 for NLR).<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The sample had a mean age of 66.2\u2009\u00b1\u200910.1\u2009years, 63.0% were female, and 86.8% were White. Mean CRP (11.5\u2009\u00b1\u200917.5\u2009mg\/L) and NLR (3.6\u2009\u00b1\u20092.2) indicated moderate to high inflammation. In the fully adjusted model, there were 2.04 (95% CI:1.02, 4.11) and 2.17 higher odds (95% CI:1.16, 4.13) of elevated CRP when comparing quartile 4 and quartile 3, respectively, to the lowest ADI quartile. Regression models were not significant for albumin or NLR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Area deprivation is associated with CRP, a marker of stress that may lead to a higher risk of chronic diseases among cancer survivors. Future studies using a sample of cancer survivors with a wider range of ADI may help to strengthen this association.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70784","type":"journal-article","created":{"date-parts":[[2025,4,5]],"date-time":"2025-04-05T21:49:51Z","timestamp":1743889791000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Area Deprivation and Clinical Biomarkers of Inflammation in Cancer Survivors of the National Institutes of Health <i>All of Us<\/i> Research Program"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8130-5927","authenticated-orcid":false,"given":"Cecily A.","family":"Byrne","sequence":"first","affiliation":[{"name":"Cancer Health Equity and Career Development Program University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8893-0637","authenticated-orcid":false,"given":"Vanessa M.","family":"Oddo","sequence":"additional","affiliation":[{"name":"Kinesiology and Nutrition Department University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7520-1004","authenticated-orcid":false,"given":"Evgenia","family":"Karayeva","sequence":"additional","affiliation":[{"name":"School of Public Health University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-5155-1812","authenticated-orcid":false,"given":"Greg","family":"Kopetsky","sequence":"additional","affiliation":[{"name":"School of Public Health University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8939-5157","authenticated-orcid":false,"given":"Sage","family":"Kim","sequence":"additional","affiliation":[{"name":"School of Public Health University of Illinois Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,4]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21820"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.31943"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/107497"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.2105\/ajph.93.7.1137"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1177\/1062860617753063"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.7326\/M13\u20102946"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2021.39593"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1749\u20106632.1999.tb08103.x"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.2307\/3090214"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/pedi.12361"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11524\u2010016\u20100034\u20100"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/PSY.0b013e31817b8ee4"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.5888\/pcd11.140090"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0045419"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.envint.2022.107164"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMsr1809937"},{"key":"e_1_2_12_18_1","unstructured":"H.Master A.Kouame H.Hollis K.Marginean andK.Rodriguez \u201c2022Q4R9 v7 Data Characterization Report: Overall All of Us Cohort Demographics \u201d2023.https:\/\/support.researchallofus.org\/hc\/en\u2010us\/articles\/14558858196628\u20102022Q4R9\u2010v7\u2010Data\u2010Characterization\u2010Report."},{"key":"e_1_2_12_19_1","unstructured":"NIH \u201cAll of Us Research Hub.\u201d Frequently Asked Questions. 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