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Thus, it is not surprising that loss or attenuation of TET enzymes is implicated in genomic hypermethylation and transcriptional reprogramming that drives cancer development. Somatic mutations in <jats:italic>TET2<\/jats:italic> are observed in the bone marrow of 5%\u201310% of healthy adults over 65\u2009years of age, imparting a hematopoietic stem cell advantage and subsequent clonal hematopoiesis of indeterminate potential (CHIP), a condition which is associated with increased risk of myeloid malignancy. Somatic <jats:italic>TET2<\/jats:italic> mutations are frequently reported in myeloid disorders, including myelodysplastic syndrome (MDS) and acute myeloid leukemia (AML). Evidence suggests that <jats:italic>TET2<\/jats:italic> mutations also affect prognosis in myeloid leukemia and other hematopoietic malignancies. However, there is a paucity of collated data on the frequency of <jats:italic>TET2<\/jats:italic> mutations in solid human cancers.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objectives<\/jats:title><jats:p>We review the published literature on <jats:italic>TET2<\/jats:italic> mutation in human solid cancers and explore their frequency and impact on patient outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Conclusions<\/jats:title><jats:p>Somatic <jats:italic>TET2<\/jats:italic> mutations are reported in numerous solid human cancers, including those arising in the skin, lung and prostate. Many of the somatic <jats:italic>TET2<\/jats:italic> mutations reported in solid cancers are recurrent, suggesting functionality. There is also evidence to suggest that somatic <jats:italic>TET2<\/jats:italic> mutations affect prognosis in solid human cancers.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70792","type":"journal-article","created":{"date-parts":[[2025,3,23]],"date-time":"2025-03-23T12:23:33Z","timestamp":1742732613000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Landscape of <scp><i>TET2<\/i><\/scp> Mutations: From Hematological Malignancies to Solid Tumors"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2348-0516","authenticated-orcid":false,"given":"Zo\u00eb L.","family":"Hawking","sequence":"first","affiliation":[{"name":"Newcastle University Centre for Cancer, Translational and Clinical Research Institute Newcastle University  Newcastle upon Tyne 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