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Financial toxicity (FT), as a concept describing the economic burden on patients, is crucial to comprehend the extent and determinants within specific contexts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>To understand the current status of FT among Chinese pancreatic cancer (PC) patients, identify risk factors for FT, and summarize the characteristics of high\u2010risk groups.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A cross\u2010sectional study involving 296 PC patients was conducted to investigate their general information, financial toxicity, quality of life, positive and negative affects, and social support. Univariate and multiple linear regression analyses were used to examine the correlation between FT and other variables.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The PC patient's FT score was 54.27\u2009\u00b1\u200914.50, with 25.7% being forced to change their work status due to the disease diagnosis and 29.4% exhibiting economically related treatment nonadherence behaviors. Factor analysis showed financial toxicity associated with fewer household savings, more total out\u2010of\u2010pocket (OOP) costs, treatment nonadherence, unemployment, diminished positive affect, and insufficient social support.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p><jats:styled-content style=\"fixed-case\">FT<\/jats:styled-content> was highly prevalent among <jats:styled-content style=\"fixed-case\">PC<\/jats:styled-content> patients and associated with factors such as household savings and total <jats:styled-content style=\"fixed-case\">OOP<\/jats:styled-content> costs. There was a need to identify and manage patients exhibiting high\u2010risk characteristics and to implement targeted interventions to mitigate their economic burden.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70799","type":"journal-article","created":{"date-parts":[[2025,4,19]],"date-time":"2025-04-19T04:43:04Z","timestamp":1745037784000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Risk Factors for Financial Toxicity in Patients With Pancreatic Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7627-9362","authenticated-orcid":false,"given":"Jing","family":"Wang","sequence":"first","affiliation":[{"name":"Hospice Care Research Center Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jialu","family":"Cui","sequence":"additional","affiliation":[{"name":"Hospice Care Research Center Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaoyuan","family":"Wang","sequence":"additional","affiliation":[{"name":"TianJin Medical University Cancer Institute and Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhihua","family":"Li","sequence":"additional","affiliation":[{"name":"TianJin Medical University Cancer Institute and Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yang","family":"Liu","sequence":"additional","affiliation":[{"name":"TianJin Medical University Cancer Institute and Hospital Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baoxin","family":"Shi","sequence":"additional","affiliation":[{"name":"Hospice Care Research Center Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,4,18]]},"reference":[{"key":"e_1_2_14_2_1","doi-asserted-by":"publisher","DOI":"10.1053\/j.gastro.2023.02.012"},{"key":"e_1_2_14_3_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11427-022-2218-x"},{"key":"e_1_2_14_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41575-021-00457-x"},{"key":"e_1_2_14_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.pan.2020.09.002"},{"key":"e_1_2_14_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12029-022-00821-3"},{"key":"e_1_2_14_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2468-1253(21)00147-3"},{"key":"e_1_2_14_8_1","doi-asserted-by":"publisher","DOI":"10.1080\/0284186X.2021.1892821"},{"key":"e_1_2_14_9_1","volume-title":"Pharmacoeconomic Study of Three Chemotherapy Regimens for Metastatic Pancreatic Cancer","author":"Hu X.","year":"2020"},{"key":"e_1_2_14_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.apjon.2024.100443"},{"key":"e_1_2_14_11_1","doi-asserted-by":"publisher","DOI":"10.3389\/fphar.2021.778940"},{"issue":"4","key":"e_1_2_14_12_1","first-page":"623","article-title":"Out\u2010Of\u2010Pocket and Reimbursed Expenses of Inpatients With Major Noncommunicable Chronic Diseases in China, 2013","volume":"37","author":"Wang J.","year":"2021","journal-title":"Chinese Journal of Public Health"},{"key":"e_1_2_14_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00520-021-06762-0"},{"key":"e_1_2_14_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2024.6872"},{"key":"e_1_2_14_15_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amjmed.2018.05.020"},{"issue":"2","key":"e_1_2_14_16_1","article-title":"Financial Toxicity, Part I: A New Name for a Growing Problem","volume":"27","author":"Zafar S. 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