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However, available data are limited, especially in understudied geographic locations. In this study, we investigated additional measures of potential cancer disparity and focused on examining rural\u2013urban prostate cancer disparity in Nebraska residents.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Patients diagnosed with prostate cancer from 1991 to 2023 living in Nebraska were identified in the integrated Cancer Repository for Cancer Research (iCaRe2) and categorized as rural and urban by rural\u2013urban commuting area (RUCA) codes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Results are presented as mean\u2009\u00b1\u2009standard deviation. The iCaRe2 patient registry contained data on 765 men with prostate cancer living in Nebraska, 621 (81.2%) of whom were urban residents and 144 (18.8%) of whom were rural residents. Rural residents were diagnosed with prostate cancer 3.1\u2009years younger than urban residents (rural: 65.6\u2009\u00b1\u20098.21\u2009years, urban: 68.7\u2009\u00b1\u20099.08\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Rural residents died of prostate cancer 4.2\u2009years younger than urban residents (rural: 72.9\u2009\u00b1\u20099.75\u2009years, urban: 77.1\u2009\u00b1\u20098.85\u2009years, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001). Analyses of Gleason score and AJCC stage did not reveal statistically significant differences between rural and urban residents. OS was similar between rural and urban men in Nebraska with prostate cancer, congruent with currently published literature.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Our analysis demonstrates that rural patients in Nebraska are diagnosed and die with prostate cancer at younger ages compared to urban patients. Our findings offer strategies to better define and delineate rural\u2013urban cancer disparity and support future, more robust investigations to consider novel approaches to determining disparities in cancer disease course.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70812","type":"journal-article","created":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T03:54:05Z","timestamp":1742874845000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disparities Between Rural and Urban Patients With Prostate Cancer in Nebraska"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3907-9409","authenticated-orcid":false,"given":"Cassie","family":"Liu","sequence":"first","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, Fred &amp; Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA"},{"name":"Division of Oncology and Hematology, Department of Internal Medicine, Fred &amp; Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kaeli K.","family":"Samson","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, College of Public Health University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleg","family":"Shats","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, Fred &amp; Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Raymond","family":"Bergan","sequence":"additional","affiliation":[{"name":"Eppley Institute for Research in Cancer and Allied Diseases, Fred &amp; Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA"},{"name":"Division of Oncology and Hematology, Department of Internal Medicine, Fred &amp; Pamela Buffett Cancer Center University of Nebraska Medical Center  Omaha Nebraska USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,3,24]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.amepre.2013.10.017"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.ss6810a1"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/OP.23.00626"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-17-0430"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-18-0807"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28037"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1097\/JU.0000000000000500"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15215171"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15071939"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2023.01.035"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.34848"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.radonc.2024.110092"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2022.12246"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-020-03483-7"},{"issue":"10","key":"e_1_2_12_16_1","first-page":"1704","article-title":"Cancer Health Effects of Pesticides: Systematic Review","volume":"53","author":"Bassil K. 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