{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:05:52Z","timestamp":1753862752670,"version":"3.41.2"},"reference-count":27,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2025,4,1]],"date-time":"2025-04-01T00:00:00Z","timestamp":1743465600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR002377"],"award-info":[{"award-number":["UL1TR002377"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Objective<\/jats:title><jats:p>To explore pre\u2013hematopoietic stem cell transplant (HSCT) demographic, disease, and psychological factors predictive of future transplant regret and to determine post\u2010HSCT variables associated with regret.<\/jats:p><\/jats:sec><jats:sec><jats:title>Patients and Methods<\/jats:title><jats:p>HSCT candidates participated in a prospective cohort study (June 2008\u2013October 2013) examining health behaviors and HSCT outcomes, including completion of standardized surveys at pre\u2010HSCT (baseline) and 1\u2010year post\u2010HSCT. Cases were participants that endorsed regret at 1\u2010year post\u2010HSCT follow\u2010up, and controls were participants without regret at 1 year, matched on age, sex, and transplant type. For cases and controls, pre\u2010HSCT psychosocial evaluations were abstracted from the electronic health record and coded to determine the Psychosocial Assessment of Candidates for Transplantation score, psychosocial stressors, and mental health diagnoses. The association of selected factors with regret was estimated with odds ratios and 95% confidence intervals from conditional logistic regression models.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>At post\u2010HSCT, 49 participants of 638 endorsed transplant regret (8%) and formed the case group; 98 controls were matched from remaining participants. Cases and controls were well matched on age (56.6 vs. 57.2\u2009years), sex (both groups 34.7% female), and transplant type (both groups 81.6% autologous). After controlling for the number of hospitalizations and active treatment status, conditional logistic regression revealed that patients who endorsed regret were 3.7 times (95% CI\u2009=\u20091.37\u20139.69, <jats:italic>p<\/jats:italic>\u2009=\u20090.008) more likely to not be in remission compared to controls at 1\u2010year post\u2010HSCT.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>Matched case\u2013control analyses revealed that no pre\u2010HSCT variables collected during the pre\u2010HSCT evaluation period were predictive of transplant regret, while poorer outcomes at 1\u2010year after transplant were associated with regret.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70828","type":"journal-article","created":{"date-parts":[[2025,4,2]],"date-time":"2025-04-02T09:35:59Z","timestamp":1743586559000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of Transplant Regret: A Case\u2013Control Study Nested Within a Prospective Cohort of <scp>HSCT<\/scp> Recipients"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3041-9518","authenticated-orcid":false,"given":"Janae L.","family":"Kirsch","sequence":"first","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"James R.","family":"Cerhan","sequence":"additional","affiliation":[{"name":"Division of Epidemiology, Department of Health Sciences Research Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William J.","family":"Hogan","sequence":"additional","affiliation":[{"name":"Division of Hematology, Department of Medicine, College of Medicine Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Holly C.","family":"Edwards","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christi A.","family":"Patten","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"},{"name":"Behavioral Health Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tabetha","family":"Brockman","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"},{"name":"Behavioral Health Research Program Mayo Clinic  Rochester Minnesota USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christine","family":"Hughes","sequence":"additional","affiliation":[{"name":"Department of Psychiatry and Psychology Mayo Clinic  Rochester Minnesota USA"},{"name":"Behavioral Health 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