{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T17:49:32Z","timestamp":1791395372915,"version":"4.3.3"},"reference-count":15,"publisher":"Wiley","issue":"6","license":[{"start":{"date-parts":[[2025,3,25]],"date-time":"2025-03-25T00:00:00Z","timestamp":1742860800000},"content-version":"vor","delay-in-days":24,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,3]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Chimeric Antigen Receptor (CAR) T\u2010cell therapy has arisen as a revolutionary treatment for hematologic malignancies. Our study aimed to evaluate how sex differences affect outcomes and complications following CAR T\u2010cell therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Utilizing the Nationwide Readmissions Database (2018\u20132020), we identified patients and divided them into male and female groups. Hospital outcomes and complications were compared among these two groups after propensity score matching to match groups based on comorbidities, producing two comparable cohorts.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>We analyzed 2928 patients (1832 males, 62.6%, mean age 60.3\u2009\u00b1\u200913.7\u2009years; 1096 females, 37.4%, mean age 59.1\u2009\u00b1\u200913.8\u2009years). After propensity score matching (1:1ratio), 1092 males and females were compared. There were no significant sex differences in early mortality (adjusted odd ratios (aOR): 1.04 [95% CI 0.69\u20131.57]), 30\u2010day readmissions (aOR: 1.05 [95% CI 0.86\u20131.30]), or nonhome discharge (aOR: 0.89 [95% CI 0.60\u20131.31]). Females had higher odds of leukopenia (aOR: 1.26 [95% CI 1.06\u20131.50]) but lower odds of acute kidney injury (aOR: 0.68 [95% CI 0.52\u20130.88]).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>No sex differences were found in hospital outcomes, including early mortality, 30\u2010day readmission, and nonhome discharge after CAR T\u2010cell therapy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70831","type":"journal-article","created":{"date-parts":[[2025,3,27]],"date-time":"2025-03-27T03:03:38Z","timestamp":1743044618000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Sex Differences in Outcomes of Chimeric Antigen Receptor (<scp>CAR<\/scp>) T\u2010Cell Therapy"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-7983-2928","authenticated-orcid":false,"given":"Jia Yi","family":"Tan","sequence":"first","affiliation":[{"name":"Department of Internal Medicine New York Medical College at Saint Michael's Medical Center  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong Hao","family":"Yeo","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine\/Pediatrics Corewell Health  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermon Wong Kha","family":"Kin","sequence":"additional","affiliation":[{"name":"Universiti Malaysia Sabah  Kota Kinabalu Malaysia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qi Xuan","family":"Ang","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine Sparrow Health System and Michigan State University  East Lansing Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammad Muhsin","family":"Chisti","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Corewell Health William Beaumont University Hospital  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Ezekwudo","sequence":"additional","affiliation":[{"name":"Hematology and Oncology Corewell Health William Beaumont University Hospital  Royal Oak Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Talal","family":"Hilal","sequence":"additional","affiliation":[{"name":"Division of Hematology and Medical Oncology Mayo Clinic  Phoenix Arizona USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,3,25]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(18)30864-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1804980"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(20)31366-0"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.4797"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0106745"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2016.147"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023010624"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41591-024-03084-6"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2023-186510"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/07853890.2022.2136748"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.997589"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/ckj\/sfae027"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12882-018-1122-z"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2022.822604"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063544"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70831","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,27]],"date-time":"2025-05-27T12:18:48Z","timestamp":1748348328000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70831"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2025,3]]}},"alternative-id":["10.1002\/cam4.70831"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70831","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"2024-12-26","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-17","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-03-25","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70831"}}