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Secondary prevention through screening faces challenges in public engagement, often leading to late\u2010stage diagnoses. Recent advancements in novel anti\u2010HPV drugs offer expanded opportunities for cervical cancer management.<\/jats:p><\/jats:sec><jats:sec><jats:title>Aim<\/jats:title><jats:p>This review examines emerging anti\u2010HPV therapeutics to provide insights into innovative strategies for cervical cancer prevention and treatment.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a systematic analysis of published studies investigating anti\u2010HPV agents, focusing on their molecular mechanisms and clinical efficacy in cervical cancer prevention.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results &amp; Conclusions<\/jats:title><jats:p>Multiple promising anti\u2010HPV agents have been identified, including 3\u2010hydroxyphthalic anhydride\u2010modified bovine \u03b2\u2010lactoglobulin (3HP\u2010\u03b2\u2010LG), carrageenan, defensins, and 25\u2010hydroxycholesterol (25HC). These compounds exert antiviral effects through distinct mechanisms: 3HP\u2010\u03b2\u2010LG competitively inhibits viral attachment, carrageenan blocks HPV entry via heparan sulfate mimicry, defensins inhibit the dissociation of viral capsid, and 25HC activates cholesterol\u2010mediated antiviral pathways. They have demonstrated strong inhibitory effects on HPV infection, making them novel therapeutic candidates for the prevention and treatment of cervical cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70847","type":"journal-article","created":{"date-parts":[[2025,4,7]],"date-time":"2025-04-07T05:29:38Z","timestamp":1744003778000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Advances in the Prevention of Cervical Cancer by Anti\u2010Human Papillomavirus Agents"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-3071-4858","authenticated-orcid":false,"given":"Hangdi","family":"Chen","sequence":"first","affiliation":[{"name":"Department of Clinical Medicine School of Medicine, Hangzhou City University  Hangzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kai","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Clinical 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