{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T11:55:00Z","timestamp":1770465300729,"version":"3.49.0"},"reference-count":28,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T00:00:00Z","timestamp":1715126400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,5]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Aims<\/jats:title><jats:p>To investigate the effect of Self\u2010designed Metabolic Equivalent Exercises (SMEE) on cancer\u2010related fatigue in patients with gastric cancer.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>130 patients with gastric cancer admitted to Department of Oncology of a tertiary hospital in Shanghai were enrolled and assessed for eligibility. After excluding 1 patient who declined to participate, 129 eligible patients were randomly assigned into SMEE (<jats:italic>n<\/jats:italic>\u2009=\u200965) and control (<jats:italic>n<\/jats:italic>\u2009=\u200964) groups. The Revised Piper Fatigue Scale (RPFS) and EORTC QLQ\u2010C30 Quality of Life Scale were used to measure cancer\u2010caused fatigue and quality of life, respectively, in both groups at the first admission and after 3\u2009months.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>After excluding patients who did not receive allocated intervention due to medical (<jats:italic>n<\/jats:italic>\u2009=\u20093) and personal (<jats:italic>n<\/jats:italic>\u2009=\u20092) reasons, those who were lost to follow\u2010up (<jats:italic>n<\/jats:italic>\u2009=\u20093), and those who had discontinued intervention (<jats:italic>n<\/jats:italic>\u2009=\u20092), 119 patients (64 in the SMEE group and 55 in the control group) were included for analysis. There were no statistically significant differences in the RPFS or QLQ\u2010C30 score between the two groups at baseline. After 3\u2009months, the total RPFS score of the SMEE group was significantly lower than that of the control group (2.86\u2009\u00b1\u20091.75 vs. 4.65\u2009\u00b1\u20091.29, <jats:italic>p<\/jats:italic>\u2009=\u20090.009), with significant improvements in affective meaning (0.83\u2009\u00b1\u20090.92 vs. 1.13\u2009\u00b1\u20090.77, <jats:italic>p<\/jats:italic>\u2009=\u20090.044) and sensory (0.70\u2009\u00b1\u20090.71 vs. 1.00\u2009\u00b1\u20090.54, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) subscales; in the SMEE group, QLQ\u2010C30 scores in somatic (2.00\u2009\u00b1\u20090.27 vs. 1.31\u2009\u00b1\u20090.26, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), emotional (2.67\u2009\u00b1\u20090.58 vs. 2.07\u2009\u00b1\u20090.48, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and social (3.23\u2009\u00b1\u20090.58 vs. 1.64\u2009\u00b1\u20090.51, <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) functioning were significantly higher than those in the control group, with significant improvements in fatigue (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), nausea\/vomiting (<jats:italic>p<\/jats:italic>\u2009=\u20090.014), shortness of breath (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), constipation (<jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and diarrhea (<jats:italic>p<\/jats:italic>\u2009=\u20090.001) dimensions.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>The self\u2010programmed metabolic equivalent manipulation as an exercise intervention could effectively reduce the degree of cancer\u2010caused fatigue and improve quality of life in patients with gastric cancer.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7085","type":"journal-article","created":{"date-parts":[[2024,5,8]],"date-time":"2024-05-08T08:41:46Z","timestamp":1715157706000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["The effect of self\u2010designed 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