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Follow\u2010ups have been arranged at the time before plaque implantation surgery, and 1\u2009month, 3\u2009months, 6\u2009months, 12\u2009months, 18\u2009months, and 24\u2009months after iodine\u2010125 plaque removal.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CM patients after PRT demonstrated a significant decrease in retinal arterial oxygen concentration (CO<jats:sub>2<\/jats:sub><jats:sup>a<\/jats:sup>), arterial oxygen saturation (SO<jats:sub>2<\/jats:sub><jats:sup>a<\/jats:sup>), oxygen utilization (SO<jats:sub>2<\/jats:sub><jats:sup>av<\/jats:sup>, CO<jats:sub>2<\/jats:sub><jats:sup>av<\/jats:sup>), and metabolism (oxygen extraction fraction, OEF) over time. However, there was no significant difference in SO<jats:sub>2<\/jats:sub> and CO<jats:sub>2<\/jats:sub> compared with healthy controls. Systolic time (Time_sr), acceleration time index (ATI), and resistivity index (RI) gradually increase over time; ATI and RI were significantly higher than those of the healthy controls. At baseline, mean arterial blood flow velocity (BFVa) and mean arterial retinal blood flow (RBFa) in CM eyes were significantly higher than those in the healthy control group. BFVa and RBFa showed a decreasing trend over time after PRT. In addition, some retinal oxygen kinetics and hemodynamic indicators were also correlated with tumor size, patient gender, and age.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CM patients after iodine\u2010125 plaque radiotherapy had significant retinal and vascular changes. Future research should focus on rapidly screening radiation microvascular complications and exploring more timely and effective interventions to protect visual function in CM patients.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70854","type":"journal-article","created":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:11:23Z","timestamp":1745493083000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Retinal Oxygen Kinetics and Hemodynamics in Choroidal Melanoma After Iodine\u2010125 Plaque Radiotherapy Using a Novel Structural\u2010Functional Imaging Analysis System"],"prefix":"10.1002","volume":"14","author":[{"given":"Haihan","family":"Zhang","sequence":"first","affiliation":[{"name":"Beijing Tongren Eye Center, Beijing Key Laboratory of Intraocular Tumor Diagnosis and Treatment, Beijing Ophthalmology and Visual Sciences Key Lab, Medical Artificial Intelligence Research and Verification Key Laboratory of 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