{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T12:26:26Z","timestamp":1791721586083,"version":"4.3.4"},"reference-count":44,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,8]],"date-time":"2025-05-08T00:00:00Z","timestamp":1746662400000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100004608","name":"Natural Science Foundation of Jiangsu Province","doi-asserted-by":"publisher","award":["BK20210230"],"award-info":[{"award-number":["BK20210230"]}],"id":[{"id":"10.13039\/501100004608","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81672551"],"award-info":[{"award-number":["81672551"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81872089"],"award-info":[{"award-number":["81872089"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82102799"],"award-info":[{"award-number":["82102799"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Chemotherapy and androgen\u2010deprivation treatment are the curative approaches utilized to suppress prostate cancer (PCa) progression. However, drug resistance and metastasis are extensive and hard to overcome even though remarkable progress has been made in recent decades. The cancer stem cell\u2010related theoretical model explains the distinct molecular characteristics of cancer, its relapse, metastasis, and drug resistance. Meanwhile, noncoding RNA functions in the formation of drug resistance and metastasis in most cancers. The long intergenic nonprotein coding RNA 908 (LINC00908) has been reported to restrain cell proliferation, migration, and invasion of some cancers like triple\u2010negative breast cancer, diffuse large B\u2010cell lymphoma, PCa, and so on. However, its role in stemness for PCa remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We delved into the impact of LINC00908 in PCa cell stemness and the principal molecular mechanism. Then, the impact of LINC00908 on PCa cell stemness and its corresponding mechanism was explored by using functional assays and bioinformatics evaluation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>We found that LINC00908 was low\u2010expressed in PCa cells, and it exerted suppressive functions in PCa cell stemness and tumor growth. Additionally, we revealed that LINC00908 down\u2010regulation was mediated by the HDAC2\u2010p300\u2010YY1 transcription complex. Moreover, LINC00908 up\u2010regulated glycogen synthase kinase 3 beta (GSK3B) via sponging miR\u20103179. Meanwhile, LINC00908 deployed DEAD\u2010box helicase 3 X\u2010linked (DDX3X) to facilitate the stabilization of F\u2010box and WD repeat domain containing 2 (FBXW2) mRNA. Importantly, LINC00908 enhanced GSK3B and FBXW2 expression to induce the ubiquitination of \u03b2\u2010catenin protein, leading to Wnt pathway inactivation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>These results reveal that LINC00908 inhibits PCa cell stemness via inactivating the GSK3B\/FBXW2\u2010regulated Wnt pathway, which might enrich people's knowledge of PCa stemness and provide some new potential biomarkers for PCa.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70887","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:18:28Z","timestamp":1747196308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["<scp>LINC00908<\/scp>\n                    Inactivates Wnt\/\u03b2\u2010Catenin Signaling Pathway to Inhibit Prostate Cancer Cell Stemness via Upregulating\n                    <scp>GSK3B<\/scp>\n                    and\n                    <scp>FBXW2<\/scp>"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7043-6307","authenticated-orcid":false,"given":"Han","family":"Guan","sequence":"first","affiliation":[{"name":"Department of Urology The First Affiliated Hospital of Bengbu Medical University  Bengbu China"},{"name":"Department of Urology Affiliated Zhongda Hospital of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Zhongda Hospital of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-8888-2557","authenticated-orcid":false,"given":"Lilin","family":"Wan","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Zhongda Hospital of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Can","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Urology Affiliated Zhongda Hospital of Southeast University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifeng","family":"Xue","sequence":"additional","affiliation":[{"name":"Department of Urology Changzhou JinTan First People's Hospital  Changzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0892-6102","authenticated-orcid":false,"given":"Ninghan","family":"Feng","sequence":"additional","affiliation":[{"name":"Department of Urology Wuxi No. 2 Hospital, Nanjing Medical University  Wuxi China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenggui","family":"Zhao","sequence":"additional","affiliation":[{"name":"Department of Laboratory Affiliated Zhongda Hospital of Southeast University  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