{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,27]],"date-time":"2025-10-27T20:14:33Z","timestamp":1761596073983,"version":"3.41.2"},"reference-count":46,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T00:00:00Z","timestamp":1744934400000},"content-version":"vor","delay-in-days":17,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>This study examined whether sick leave due to severe stress (stress leave) and duration of leave are associated with future cancer risk.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We conducted a matched case\u2013control study using complete\u2010population data from Swedish national registers (2005 to 2018), including 516,678 primary cancer cases and 2,357,433 matched controls. Odds ratios (OR) were calculated by conditional logistic regression and adjusted for pre\u2010specified confounders.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Stress leave of any duration, reported to the Swedish Social Insurance Register, was associated with a slightly increased cancer risk, with the highest risk estimate for 1\u201330 versus 0\u2009days (adjusted OR 1.05, 95% CI 1.02\u20131.09). In men, a clear exposure\u2010response trend was present. We observed increased risks of prostate cancer (adjusted OR for &gt;\u200990\u2009days: 1.10, 95% CI 1.01\u20131.20) and cervical cancer (adjusted OR for &gt;\u200990\u2009days: 1.11, 95% CI 1.05\u20131.17, including cancer in\u00a0situ). In etiology\u2010based analyses, a positive association was found for smoking\u2010related cancers, and the risk relationship for non\u2010cervical HPV\u2010related cancers was similar to that for cervical cancer. Risk estimates were above one for several types of stress in relation to overall cancer risk, including an exposure\u2010response trend for acute stress reactions (p\u2010trend 4.0 \u00d7\u200910<jats:sup>\u22124<\/jats:sup>) but a null association for post\u2010traumatic stress disorder.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Stress leave was associated with a modestly higher risk of cancer overall and prostate and cervical cancers specifically. Regardless of whether the link is biological or reflective of lifestyle mediators or for cervical cancer, lower participation in screening, these findings suggest a potential relevance of severe stress for cancer prevention.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70888","type":"journal-article","created":{"date-parts":[[2025,4,18]],"date-time":"2025-04-18T07:59:51Z","timestamp":1744963191000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sick Leave due to Stress and Subsequent Cancer Risk, a Swedish National Registry Study of 516,678 Cancer Cases"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4864-7842","authenticated-orcid":false,"given":"Jenny","family":"Hadrevi","sequence":"first","affiliation":[{"name":"Section of Sustainable Health, Department of Global Health and Epidemiology Ume\u00e5 University  Ume\u00e5 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