{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,24]],"date-time":"2026-01-24T15:15:25Z","timestamp":1769267725679,"version":"3.49.0"},"reference-count":13,"publisher":"Wiley","issue":"8","license":[{"start":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T00:00:00Z","timestamp":1744675200000},"content-version":"vor","delay-in-days":14,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82100169"],"award-info":[{"award-number":["82100169"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,4]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Backgrounds<\/jats:title><jats:p>Mitoxantrone hydrochloride liposome (Lipo\u2010MIT) has shown clinical benefits in various tumors. However, there is no prospective study evaluating its effectiveness and safety in relapsed\/refractory multiple myeloma (RRMM). A phase I trial of bortezomib, Lipo\u2010MIT, and dexamethasone (VMitD) with the primary endpoints being safety and efficacy was performed.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Twenty subjects were enrolled this study, and the dose of Lipo\u2010MIT was designed to be 12, 16, and 20\u2009mg\/m<jats:sup>2<\/jats:sup> at Day 1 combined with bortezomib and dexamethasone.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The most common grade 3\/4 non\u2010hematologic adverse event was pneumonia (20%). The most frequently observed grade 3\/4 hematologic toxicity included thrombocytopenia (70%), neutropenia (55%), lymphopenia (30%), and anemia (10%). Fifteen subjects received at least one efficacy evaluation, including 60% (9\/15) with a very good partial response (VGPR) or better, resulting in an overall response rate (ORR) of 86.7% (13\/15).<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>This is the first report about the novel triplet regimen VMitD, including Lipo\u2010MIT for RRMM, which was well tolerated and demonstrated efficacy. Further studies are required to assess the outcomes more accurately and to evaluate its effectiveness in comparison to other salvage regimens containing proteasome inhibitors and anthracyclines.<\/jats:p><jats:p><jats:bold>Trial Registration:<\/jats:bold> ClinicalTrials.gov identifier: NCT05052970<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70890","type":"journal-article","created":{"date-parts":[[2025,4,15]],"date-time":"2025-04-15T13:58:21Z","timestamp":1744725501000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Bortezomib, Mitoxantrone Hydrochloride Liposome, and Dexamethasone for Relapsed\/Refractory Multiple Myeloma: A Multi\u2010Center, Open\u2010Label Phase I Trial"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7059-8277","authenticated-orcid":false,"given":"Ya\u2010Lan","family":"Zhou","sequence":"first","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jin\u2010Qiao","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Third Hospital of Hebei Medical University  Hebei China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wei","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Affiliated Hospital of Harbin Medical University  Heilongjiang China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6436-1492","authenticated-orcid":false,"given":"Li","family":"Bao","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Jishuitan Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bai\u2010Jun","family":"Fang","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Cancer Hospital of Zhengzhou University and Henan Cancer Hospital  Henan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Da","family":"Gao","sequence":"additional","affiliation":[{"name":"Department of Hematology Affiliated Hospital of Inner Mongolia Medical University  Inner Mongolia China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li\u2010Ping","family":"Su","sequence":"additional","affiliation":[{"name":"Department of Hematology Shanxi Provincial Cancer Hospital  Shanxi China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6298-8489","authenticated-orcid":false,"given":"Wen\u2010Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Guang\u2010Zhong","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hematology, Beijing Chaoyang Hospital Capital Medical University  Beijing China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,4,15]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-024-00529-7"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27422"},{"key":"e_1_2_9_4_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2017.329"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1002\/med.21364"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1396819"},{"key":"e_1_2_9_7_1","first-page":"365","article-title":"Clinical Analysis of Mitoxantrone Liposome in the Treatment of Children With High\u2010Risk Acute Myeloid Leukemia","volume":"32","author":"Jifao Y. Q.","year":"2024","journal-title":"Zhongguo Shi Yan Xue Ye Xue Za Zhi"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa030288"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.28325"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1038\/leu.2009.173"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2006.10.5460"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-18-1909"},{"key":"e_1_2_9_13_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1606038"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2019000722"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70890","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T11:12:28Z","timestamp":1745493148000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70890"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,4]]},"references-count":13,"journal-issue":{"issue":"8","published-print":{"date-parts":[[2025,4]]}},"alternative-id":["10.1002\/cam4.70890"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70890","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,4]]},"assertion":[{"value":"2025-02-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-15","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70890"}}