{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,27]],"date-time":"2026-06-27T16:44:15Z","timestamp":1782578655526,"version":"3.54.5"},"reference-count":41,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82373296"],"award-info":[{"award-number":["82373296"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background and Aim<\/jats:title>\n                    <jats:p>Undifferentiated carcinoma with osteoclast\u2010like giant cells of pancreas (UCOGCP) is a rare type of pancreatic adenocarcinoma (PDAC). However, the efficacy of chemotherapy in UCOGCP has not been evaluated so far due to the scarcity of cases. This study aims to evaluate the efficacy of chemotherapy in UCOGCP combined with previous individual participant data (IPD) and SEER database data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Forty\u2010nine patients with UCOGCP were enrolled from the Surveillance, Epidemiology, and End Results (SEER) database. Based on whether they had received chemotherapy or not, we divided UCOGCP patients into chemotherapy group (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200932) and non\u2010chemotherapy group (\n                      <jats:italic>N<\/jats:italic>\n                      \u2009=\u200917). The survival time of the chemotherapy group and non\u2010chemotherapy group was assessed by Kaplan\u2013Meier analysis and Cox analysis. IPD data for UCOGCP were collected in PubMed, Embase, Cochrane, and ScienceDirect. The results based on the SEER database were verified by IPD meta\u2010analysis.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The Kaplan\u2013Meier analysis indicated that patients who received chemotherapy experienced a longer survival time compared to those who did not (OS:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00061, CSS:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00047). Univariate (OS: HR: 0.31 [0.15, 0.63],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001; CSS: HR: 0.28 [0.13, 0.60],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001) and multivariate (OS: HR: 0.33 [0.14, 0.78],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012; CSS: HR: 0.30 [0.12, 0.73],\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.008) Cox regression showed that chemotherapy was the independent prognostic protective factor for UCOGCP. IPD meta\u2010analysis showed that chemotherapy can significantly improve the prognosis of patients who received primary tumor resection (PTR,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0084).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>In contrast to not receiving chemotherapy, chemotherapy is effective in prolonging survival in UCOGCP patients with or without PTR. This provides a foundation for the use of UCOGCP chemotherapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70894","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T07:24:27Z","timestamp":1746861867000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["The Survival Benefits of Chemotherapy for Undifferentiated Carcinoma With Osteoclast\u2010Like Giant Cells of Pancreas: A Retrospective Analysis and Individual Participant Data Meta\u2010Analysis"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7075-9173","authenticated-orcid":false,"given":"Ouyang","family":"Yonghao","sequence":"first","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhi","family":"Li","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yi","family":"Xiao","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Cai","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannian","family":"Liao","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denghuan","family":"Lu","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Zhu","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongxi","family":"Shen","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xinbo","family":"Wang","sequence":"additional","affiliation":[{"name":"Research Institute of General Surgery, Jinling Hospital, Affiliated Hospital of Medical School Nanjing University  Nanjing China"},{"name":"Department of General Surgery, Jinling Hospital, the First School of Clinical Medicine Southern Medical University  Nanjing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,5,10]]},"reference":[{"key":"e_1_2_9_2_1","doi-asserted-by":"publisher","DOI":"10.1002\/1097-0142(196808)22:2<333::AID-CNCR2820220210>3.0.CO;2-A"},{"key":"e_1_2_9_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v20.i10.2725"},{"key":"e_1_2_9_4_1","volume-title":"WHO Classification of Tumours of the Digestive System","author":"Bosman F. T.","year":"2010"},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1097\/00006676-199905000-00014"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i2.694"},{"key":"e_1_2_9_7_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2023.13838"},{"key":"e_1_2_9_8_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12943-022-01596-8"},{"key":"e_1_2_9_9_1","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000689"},{"key":"e_1_2_9_10_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40792-022-01385-x"},{"key":"e_1_2_9_11_1","doi-asserted-by":"publisher","DOI":"10.1159\/000506732"},{"key":"e_1_2_9_12_1","doi-asserted-by":"publisher","DOI":"10.1093\/jscr\/rjac288"},{"issue":"2","key":"e_1_2_9_13_1","first-page":"179","article-title":"Osteoclast\u2010Like Giant Cell Undifferentiated Carcinoma of the Pancreas: A Case Report","volume":"14","author":"Jiang J.","year":"2021","journal-title":"International Journal of Clinical and Experimental Pathology"},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1089\/pancan.2021.0004"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms25063285"},{"key":"e_1_2_9_16_1","first-page":"147","volume-title":"Principles and Practice of Systematic Reviews and Meta\u2010Analysis","author":"Abhijeet R.","year":"2021"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamasurg.2021.0522"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1093\/jncics\/pkae097"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2014.01.002"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.29271\/jcpsp.2022.07.934"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijscr.2024.109419"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02830-8"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2018.07.006"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2021.7001"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12876-020-01362-4"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.3892\/ol.2014.2325"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1007\/s13691-017-0305-y"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00428-020-02889-3"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.2169\/internalmedicine.3271-19"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2022.06.043"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0021052"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1016\/0277-9536(86)90352-7"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.49.6489"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1159\/000448878"},{"issue":"9","key":"e_1_2_9_35_1","first-page":"1600","article-title":"A Case of Preoperative Diagnosis of Anaplastic Pancreatic Cancer With Osteoclast\u2010Like Giant Cells Which Was Classified as ts1 (Diameter, 13\u2009mm) Using Endoscopic Ultrasound\u2010Fine Needle Aspiration","volume":"62","author":"Yamamura M.","year":"2020","journal-title":"Gastroenterological Endoscopy"},{"key":"e_1_2_9_36_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-024-12795-5"},{"key":"e_1_2_9_37_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.29803"},{"key":"e_1_2_9_38_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12328-021-01415-5"},{"key":"e_1_2_9_39_1","doi-asserted-by":"publisher","DOI":"10.1155\/2023\/2916974"},{"key":"e_1_2_9_40_1","doi-asserted-by":"publisher","DOI":"10.4166\/kjg.2024.079"},{"key":"e_1_2_9_41_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41392-024-01948-4"},{"key":"e_1_2_9_42_1","doi-asserted-by":"publisher","DOI":"10.4240\/wjgs.v16.i5.1223"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70894","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.70894","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70894","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T07:16:53Z","timestamp":1771139813000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70894"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":41,"journal-issue":{"issue":"9","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cam4.70894"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70894","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-11-01","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-04-07","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-10","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70894"}}