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Studies have shown that CENP\u2010F is closely involved in the pathogenesis of various diseases, particularly in the development and progression of malignant tumors, where it exhibits significant oncogenic activity.<\/jats:p><\/jats:sec><jats:sec><jats:title>Objective<\/jats:title><jats:p>This review aims to systematically summarize the molecular structure, subcellular localization, expression regulation, intracellular transport mechanisms, biological functions, and carcinogenic mechanisms of CENP\u2010F, as well as explore its potential value in cancer diagnosis and therapy.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>A comprehensive review and analysis of domestic and international research literature related to CENP\u2010F were conducted, focusing on its role in tumorigenesis, development, and as a therapeutic target.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>CENP\u2010F acts as an oncogene and can maintain or promote the malignant phenotype of tumor cells through multiple mechanisms, including regulating signaling pathways related to cell proliferation and apoptosis, promoting metabolic reprogramming, angiogenesis, and tumor cell invasion and metastasis. Additionally, it plays an important role in the immune microenvironment and drug resistance regulation.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>CENP\u2010F plays a key, multidimensional role in tumor biology and is a promising therapeutic target for cancer treatment. Further exploration of the core pathways through which CENP\u2010F regulates tumorigenesis and its potential for clinical translation is needed.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70949","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T11:51:19Z","timestamp":1747655479000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Centromere Protein F in Tumor Biology: Cancer's Achilles Heel"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-2527-8997","authenticated-orcid":false,"given":"Zitong","family":"Wan","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery, Air Force Medical Center Fourth Military Medical University  Beijing China"},{"name":"Department of Thoracic Surgery, Tangdu Hospital Fourth Military Medical University  Xi'an China"},{"name":"College of Life Sciences Northwestern University  Xi'an 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