{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,15]],"date-time":"2026-02-15T08:03:35Z","timestamp":1771142615158,"version":"3.50.1"},"reference-count":24,"publisher":"Wiley","issue":"9","license":[{"start":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T00:00:00Z","timestamp":1746835200000},"content-version":"vor","delay-in-days":9,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/100007449","name":"Takeda Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007449","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007533","name":"Kobayashi Foundation for Cancer Research","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007533","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008732","name":"Uehara Memorial Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008732","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP23ck0106797"],"award-info":[{"award-number":["JP23ck0106797"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["JP24ck0106908"],"award-info":[{"award-number":["JP24ck0106908"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009619","name":"Japan Agency for Medical Research and Development","doi-asserted-by":"publisher","award":["Moonshot Research and Development Program"],"award-info":[{"award-number":["Moonshot Research and Development Program"]}],"id":[{"id":"10.13039\/100009619","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      T follicular helper (Tfh) cell lymphomas, including their most prevalent form, angioimmunoblastic T\u2010cell lymphoma, frequently present with clinical symptoms, such as fever and rash, accompanied by substantial immune cell infiltration within the tumor microenvironment. These features often obscure the distinction between Tfh lymphoma and other autoimmune or inflammatory conditions. Notably, the p.Gly17Val\n                      <jats:italic>RHOA<\/jats:italic>\n                      (G17V) mutation is commonly associated with Tfh lymphomas, including angioimmunoblastic T\u2010cell lymphoma, suggesting that testing for the G17V mutation may serve as a valuable diagnostic tool. However, it remains unclear which patients would benefit the most from G17V mutation testing.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, we retrospectively reviewed the medical records of 224 patients tested for the G17V mutation as part of routine clinical practice.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      We detected G17V in 17 patients. Among Tfh lymphoma cases, the sensitivity and specificity of the G17V test were 0.533 and 0.955, respectively. We further explored the association between G17V positivity and the clinical features of patients undergoing testing for the first time (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u2009186). The G17V mutation was more frequent in patients presenting with lymphadenopathy in combination with fever or skin rash and elevated soluble interleukin\u20102 receptor levels (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The median time from G17V test submission to results was 11.6 d shorter than that for pathological diagnosis (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0009).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Given the noninvasive nature of the G17V test, its rapid administration to appropriate patients is expected to enable faster and more efficient diagnosis of Tfh lymphomas compared with conventional methods.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70955","type":"journal-article","created":{"date-parts":[[2025,5,10]],"date-time":"2025-05-10T06:46:12Z","timestamp":1746859572000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Real\u2010World Data on the p.\n                    <scp>Gly17Val RHOA<\/scp>\n                    Mutation in Diagnosing T Follicular Helper Cell Lymphomas"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9489-6943","authenticated-orcid":false,"given":"Yuri","family":"Tsuboi","sequence":"first","affiliation":[{"name":"Department of Hematology University of Tsukuba Hospital  Tsukuba Ibaraki Japan"},{"name":"Department of Hematology Graduate School of Comprehensive Human Sciences, University of Tsukuba  Tsukuba Ibaraki Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0810-7887","authenticated-orcid":false,"given":"Keiichiro","family":"Hattori","sequence":"additional","affiliation":[{"name":"Department of Hematology University of Tsukuba Hospital  Tsukuba Ibaraki Japan"},{"name":"Department of Hematology Institute of Medicine, University of Tsukuba  Tsukuba Ibaraki 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