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We aimed to examine associations between personality traits and change in physical function outcomes in survivors who completed a resistance training (RT) intervention.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Participants were 5+ year survivors in the St. Jude Lifetime Cohort. Personality traits were assessed using the Big Five Inventory 2 (\n                      <jats:styled-content style=\"fixed-case\">BFI<\/jats:styled-content>\n                      \u20102). Grip strength was measured using hand\u2010held dynamometry. Quadriceps strength was measured using isokinetic dynamometry. Walking speed was measured with the Six\u2010Minute Walk Test (\n                      <jats:styled-content style=\"fixed-case\">6MWT<\/jats:styled-content>\n                      ). Associations between personality traits and grip strength, quadriceps strength, and walking speed were evaluated using multivariable regression adjusted for gender, age at assessment, race, primary cancer diagnosis, and grade 3\u20104 chronic health conditions (National Cancer Institute Common Terminology Criteria for Adverse Events, version 4.03).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 43 survivors (mean age 34.6\u2009\u00b1\u20097.0\u2009years, 55.8% female, 67.4% white, 41.9% leukemia\/lymphoma, 3.84\u2009\u00b1\u20092.02\u2009years post\u2010intervention), mean trait scores were: agreeableness 4.2\u2009\u00b1\u20090.5, conscientiousness 3.9\u2009\u00b1\u20090.7, extraversion 3.4\u2009\u00b1\u20090.7, negative emotionality 2.6\u2009\u00b1\u20090.9, and open\u2010mindedness 3.9\u2009\u00b1\u20090.7. Mean change post\u2010intervention to follow\u2010up in grip strength was \u22122.1\u2009\u00b1\u200911.9\u2009kg, quadriceps strength \u221225.5\u2009\u00b1\u200927.2\u2009Nm\/kg, and walking speed 2.5\u2009\u00b1\u200914.0\u2009m per minute. Survivors who scored higher in conscientiousness had greater positive change in walking speed from post\u2010intervention to follow\u2010up (\n                      <jats:italic>\u03b2<\/jats:italic>\n                      \u2009=\u200911.35, SE\u2009=\u20093.50,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.003).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Personality traits may impact the maintenance of physical function in survivors past intervention windows. Further interventions should consider personality and potentially tailor follow\u2010up to preserve functioning.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.70965","type":"journal-article","created":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T04:18:28Z","timestamp":1747196308000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Associations Between Personality Traits and Longitudinal Change in Physical Function in Survivors of Childhood Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1564-7520","authenticated-orcid":false,"given":"Megan E.","family":"Ware","sequence":"first","affiliation":[{"name":"Department of Kinesiology, Health Promotion, and Recreation University of North Texas  Denton Texas USA"},{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Matthew D.","family":"Wogksch","sequence":"additional","affiliation":[{"name":"Department of Hematology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Neel","sequence":"additional","affiliation":[{"name":"Department of Surgery St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robyn E.","family":"Partin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer Q.","family":"Lanctot","sequence":"additional","affiliation":[{"name":"Cancer Center Administration St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel A.","family":"Mulrooney","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Melissa M.","family":"Hudson","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"},{"name":"Department of Oncology St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kirsten K.","family":"Ness","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Cancer Control St. Jude Children's Research Hospital  Memphis Tennessee USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,9]]},"reference":[{"key":"e_1_2_10_2_1","unstructured":"\u201cSurveillance Epidemiology and End Results Program \u201d Incidence\u2014SEER 18 Regs Research Data + Hurricane Katrina Impacted Louisiana Cases Nov 2018 Sub (2000\u20132016) <Katrina\/Rita Population Adjustment>. 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