{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:18Z","timestamp":1753862778156,"version":"3.41.2"},"reference-count":26,"publisher":"Wiley","issue":"10","license":[{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":18,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,5]]},"abstract":"<jats:title>ABSTRACT<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>Desmoid tumors (DT) are rare, locally aggressive neoplasms that affect a young population and have a tendency for recurrence. There is sparse contemporary real\u2010world data to guide practice for DT. Here, we report on a large cohort of DT patients, describing patterns of care and clinical outcomes.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>Data on DT patients first seen between 2010 and 2021 were extracted from a prospective database and supplemented with a retrospective review of hospital records. Trends in treatment use were analyzed using the Cochran\u2010Armitage test. Time\u2010to\u2010next intervention (TTNI) was estimated with the Kaplan\u2013Meier method. Imaging response was categorized using the RECIST v1.1 criteria.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>A total of 135 patients, 265 treatment episodes were analyzed. Median follow\u2010up was 4.3\u2009years. The common tumor sites were abdominal wall (27%), upper limb (20%), lower limb (16%), and intra\u2010abdominal (15%). Over time, the proportion of patients receiving no upfront treatment was stable (2010\u20132013: 31%, 2014\u20132017: 35%, 2018\u20132021: 29%; <jats:italic>p<\/jats:italic>\u2009=\u20090.5), but there was increasing first\u2010line use of NSAID\/tamoxifen (7%, 41%, 47%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001), and decreasing first\u2010line use of radiotherapy (35%, 14%, 4%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.001) and surgery (28%, 8%, 18%; <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). At 5\u2009years, the proportion not requiring treatment switch was highest following surgery (72%), radiotherapy (66%), and no upfront therapy (52%). 12% and 5% of patients without treatment achieved partial and complete imaging responses at 2\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusion<\/jats:title><jats:p>We highlight the heterogeneity and trends in DT management over a 12\u2010year period, affirming the role of active surveillance, radiotherapy, and surgery in selected patients. Medical therapies are evolving and may significantly influence the DT management paradigm.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70973","type":"journal-article","created":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T13:17:01Z","timestamp":1747660621000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Trends in Practice Patterns and Clinical Outcomes for Desmoid Tumors: A Large Single\u2010Institutional Australian Cohort"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9056-0903","authenticated-orcid":false,"given":"Joseph","family":"Sia","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephanie","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narayan","family":"Mohanakrishnan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kelvin","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel Y.","family":"Ngan","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarat","family":"Chander","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jayesh","family":"Desai","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jeremy","family":"Lewin","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen J.","family":"Luen","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David E.","family":"Gyorki","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hayden","family":"Snow","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Claudia","family":"DiBella","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sarah","family":"O'Reilly\u2010Harbidge","sequence":"additional","affiliation":[{"name":"Division of Cancer Surgery Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lisa M.","family":"Orme","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julie","family":"Chu","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology Peter MacCallum Cancer Centre  Melbourne Australia"},{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susie","family":"Bae","sequence":"additional","affiliation":[{"name":"Sir Peter MacCallum Department of Oncology University of Melbourne  Melbourne Australia"},{"name":"Department of Medical Oncology Peter MacCallum Cancer Centre  Melbourne Australia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,5,19]]},"reference":[{"key":"e_1_2_11_2_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-94-007-1685-8_2"},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-015-4632-y"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2019.11.013"},{"key":"e_1_2_11_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ctarc.2022.100562"},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2005.07.002"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa2210140"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejca.2020.10.035"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1080\/02656736.2019.1608376"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.1805"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2009.07.183"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijrobp.2018.12.012"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdt254"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0142(20000401)88:7<1517::AID-CNCR3>3.0.CO;2-9"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.21873\/anticanres.11702"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147-019-01512-z"},{"key":"e_1_2_11_17_1","doi-asserted-by":"publisher","DOI":"10.1590\/1413-785220243202e274225"},{"key":"e_1_2_11_18_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1382856"},{"key":"e_1_2_11_19_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.5329"},{"key":"e_1_2_11_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-018-6408-7"},{"key":"e_1_2_11_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejso.2020.08.009"},{"key":"e_1_2_11_22_1","doi-asserted-by":"publisher","DOI":"10.3390\/jpm13121653"},{"key":"e_1_2_11_23_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-009-0586-2"},{"key":"e_1_2_11_24_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-013-3197-x"},{"key":"e_1_2_11_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bulcan.2015.02.001"},{"key":"e_1_2_11_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/ijc.34493"},{"key":"e_1_2_11_27_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2023.1286807"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.70973","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,5,28]],"date-time":"2025-05-28T10:32:34Z","timestamp":1748428354000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.70973"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":26,"journal-issue":{"issue":"10","published-print":{"date-parts":[[2025,5]]}},"alternative-id":["10.1002\/cam4.70973"],"URL":"https:\/\/doi.org\/10.1002\/cam4.70973","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"type":"print","value":"2045-7634"},{"type":"electronic","value":"2045-7634"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"2024-06-27","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-08","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-05-19","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e70973"}}