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An age\u2010period\u2010cohort model was employed to evaluate the disparities among nations, while an autoregressive integrated moving average (ARIMA) model was employed to forecast the impending developments over the subsequent 15\u2009years.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>The study found the burden of MM continues to increase in China and the Russian Federation, with significant increases particularly in older age groups. In the United States of America, age\u2010standardised incidence rates (ASIR) and age\u2010standardised death rates (ASDR) showed a downward trend, reflecting a reduction in the burden of disease. In England and France, ASIR increased overall, but ASDR remained stable. The burden of MM was found to be significantly correlated with age, period effect, and birth cohort through age\u2010period\u2010cohort analysis. The ARIMA model predictions indicated an increasing trend in ASIR and a stable ASDR in China and the Russian Federation, while in England, France, and the United States of America, there was an overall stabilisation of ASIR and ASDR.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Significant differences in the burden of MM were found among the five countries. China and the Russian Federation are facing an increasing MM burden, particularly in older age groups, while the United States of America, England and France have made progress through early screening and treatment. The study suggests focusing on older populations, promoting early diagnosis and personalised treatment, and addressing lifestyle and environmental factors. Future research should examine risk factors across countries to inform public health policy.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.70999","type":"journal-article","created":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T13:15:23Z","timestamp":1750252523000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Long\u2010Term Trends and Projections of Multiple Myeloma Across Three Continents: A Comparative Study of China, the United States of America, the Russian Federation, England and France (1990\u20132036)"],"prefix":"10.1002","volume":"14","author":[{"given":"Huiqiang","family":"Wu","sequence":"first","affiliation":[{"name":"The Second Affiliated Hospital of Fujian Medical University  Quanzhou Fujian Province China"},{"name":"The Second Clinical Medical College Fujian Medical University  Fujian 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