{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,3]],"date-time":"2026-06-03T05:26:53Z","timestamp":1780464413358,"version":"3.54.1"},"reference-count":34,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T00:00:00Z","timestamp":1751500800000},"content-version":"vor","delay-in-days":2,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82270148"],"award-info":[{"award-number":["82270148"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>\n                      The incidence, outcomes and risk factors for AF in the\n                      <jats:italic>JAK2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>V617F<\/jats:italic>\n                      <\/jats:sup>\n                      \u2010positive MPN patients are still unknown.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      The clinical profiles of patients with\n                      <jats:italic>JAK2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>V617F<\/jats:italic>\n                      <\/jats:sup>\n                      \u2010positive MPN were retrospectively analyzed. Multivariable Cox regression analysis was performed to identify risk factors of AF, thereby developing a risk prediction model.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      A total of 439 patients were included (age 57 [12\u201387] years; 51.3% male). AF was associated with higher risks of stroke (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.036, HR\u2009=\u20091.987, 95% CI 1.047\u20133.772) and mortality (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001, HR\u2009=\u20093.857, 95% CI 1.836\u20138.103). Multivariable Cox regression showed that\n                      <jats:italic>TET2<\/jats:italic>\n                      mutation (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.042, HR\u2009=\u20094.361, 95% CI 1.053\u201318.056) and increased IL\u20101\u03b2 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.012, HR\u2009=\u20095.476, 95% CI 1.547\u201328.123) were significant risk factors for AF in patients with\n                      <jats:italic>JAK2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>V617F<\/jats:italic>\n                      <\/jats:sup>\n                      \u2010positive MPN. Nomograms were constructed, allowing patients to be categorized into high\u2010 and low\u2010risk groups. The 10\u2010year AF\u2010free survival rate was significantly lower in the high\u2010risk group (62% vs. 91.7%; log\u2010rank test:\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.002). The validation cohort confirmed that the survival without AF in the high\u2010risk group was significantly worse than that in the low\u2010risk group. The use of either interferon\u2010\u03b1 or ruxolitinib, was associated with longer AF\u2010free survival in the high\u2010risk group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>\n                      AF was significantly associated with higher risks of stroke and mortality.\n                      <jats:italic>TET2<\/jats:italic>\n                      mutation and increased IL\u20101\u03b2 were independent risk factors of AF in patients with\n                      <jats:italic>JAK2<\/jats:italic>\n                      <jats:sup>\n                        <jats:italic>V617F<\/jats:italic>\n                      <\/jats:sup>\n                      \u2010positive MPN.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71015","type":"journal-article","created":{"date-parts":[[2025,7,3]],"date-time":"2025-07-03T07:08:42Z","timestamp":1751526522000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Incidence, Outcomes and Risk Factors for Atrial Fibrillation in Patients With\n                    <i>\n                      JAK2\n                      <sup>V617F<\/sup>\n                    <\/i>\n                    \u2010Positive Myeloproliferative Neoplasms"],"prefix":"10.1002","volume":"14","author":[{"given":"Guangshuai","family":"Teng","sequence":"first","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Department of Cardiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease  Tianjin China"},{"name":"Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ke","family":"Shang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuhui","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifan","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenxiao","family":"Du","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yan","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanqi","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huiqin","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Peng","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaojing","family":"Wei","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Tse","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease  Tianjin China"},{"name":"Tianjin Institute of Cardiology  Tianjin China"},{"name":"School of Nursing and Health Studies Hong Kong Metropolitan University  Hong Kong China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4413-7490","authenticated-orcid":false,"given":"Yuan","family":"Zhou","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Experimental Hematology, National Clinical Research Center for Blood Diseases, Haihe Laboratory of Cell Ecosystem, Institute of Hematology &amp; Blood Diseases Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Tianjin China"},{"name":"Tianjin Institutes of Health Science  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory Y. H.","family":"Lip","sequence":"additional","affiliation":[{"name":"Liverpool Centre for Cardiovascular Science at University of Liverpool Liverpool John Moores University and Liverpool Heart &amp; Chest Hospital  Liverpool UK"},{"name":"Danish Center for Health Services Research, Department of Clinical Medicine Aalborg University  Aalborg Denmark"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0482-0738","authenticated-orcid":false,"given":"Tong","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Cardiology The Second Hospital of Tianjin Medical University  Tianjin China"},{"name":"Tianjin Key Laboratory of Ionic\u2010Molecular Function of Cardiovascular Disease  Tianjin China"},{"name":"Tianjin Institute of Cardiology  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Hemotology Shengjing Hospital of China Medical University  Liaoning China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2130-6300","authenticated-orcid":false,"given":"Minghui","family":"Duan","sequence":"additional","affiliation":[{"name":"Department of Hematology, Peking Union Medical College Hospital Chinese Academy of Medical Sciences &amp; Peking Union Medical College  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7493-8347","authenticated-orcid":false,"given":"Jie","family":"Bai","sequence":"additional","affiliation":[{"name":"Department of Hematology The Second Hospital of Tianjin Medical University  Tianjin China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,3]]},"reference":[{"key":"e_1_2_10_2_1","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehad670"},{"key":"e_1_2_10_3_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.2886"},{"issue":"10","key":"e_1_2_10_4_1","first-page":"1220","article-title":"Incidence and Influencing Factors of Atrial Fibrillation in Patients With Myeloproliferative Neoplasms","volume":"11","author":"Bai B.","year":"2019","journal-title":"Chinese Journal of Evidence\u2010Based Cardiovascular Medicine"},{"key":"e_1_2_10_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2023.04.021"},{"key":"e_1_2_10_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.thromres.2022.02.006"},{"issue":"45","key":"e_1_2_10_7_1","first-page":"3652","article-title":"Analysis of Risk Factors for Thromboembolism in Patients With JAK2(V617F) Gene Mutation Positive Myeloproliferative Neoplasms","volume":"103","author":"Zhang Y.","year":"2023","journal-title":"Zhonghua Yi Xue Za Zhi"},{"key":"e_1_2_10_8_1","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.120.029474"},{"issue":"12","key":"e_1_2_10_9_1","article-title":"The Impact of Cardiac Comorbidity Sequence at Baseline and Mortality Risk in Type 2 Diabetes Mellitus: A Retrospective Population\u2010Based Cohort Study","volume":"12","author":"Lee S.","year":"2022","journal-title":"Life (Basel)"},{"key":"e_1_2_10_10_1","doi-asserted-by":"publisher","DOI":"10.3390\/cells8080854"},{"key":"e_1_2_10_11_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.123.065597"},{"key":"e_1_2_10_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-022-00347-9"},{"key":"e_1_2_10_13_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood.2022015850"},{"key":"e_1_2_10_14_1","doi-asserted-by":"publisher","DOI":"10.2147\/CLEP.S122916"},{"key":"e_1_2_10_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/imt2.36"},{"key":"e_1_2_10_16_1","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/8985273"},{"key":"e_1_2_10_17_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11239-020-02175-8"},{"key":"e_1_2_10_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cpcardiol.2023.102181"},{"key":"e_1_2_10_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41569-022-00820-8"},{"key":"e_1_2_10_20_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2010.32.9490"},{"key":"e_1_2_10_21_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.23295"},{"key":"e_1_2_10_22_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-022-32927-4"},{"key":"e_1_2_10_23_1","doi-asserted-by":"publisher","DOI":"10.1111\/imr.12621"},{"key":"e_1_2_10_24_1","doi-asserted-by":"publisher","DOI":"10.1126\/scisignal.3105cm1"},{"key":"e_1_2_10_25_1","doi-asserted-by":"publisher","DOI":"10.1172\/JCI167517"},{"key":"e_1_2_10_26_1","doi-asserted-by":"publisher","DOI":"10.1161\/CIRCULATIONAHA.118.035202"},{"key":"e_1_2_10_27_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41586-021-03341-5"},{"key":"e_1_2_10_28_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bcmd.2021.102565"},{"key":"e_1_2_10_29_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacc.2017.12.037"},{"key":"e_1_2_10_30_1","doi-asserted-by":"publisher","DOI":"10.1126\/science.aag1381"},{"issue":"45","key":"e_1_2_10_31_1","first-page":"3645","article-title":"Efficacy and Safety of Pegylated Interferon Alpha\u20102b for Patients With Myeloproliferative Neoplasm","volume":"103","author":"Teng G. 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