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However, despite these promising developments, cancer\u2010related mortality remains high for common cancer types such as breast and lower female genital tract cancers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Method<\/jats:title>\n                    <jats:p>Here, we synthesize recent findings on the prognostic relevance of tumor\u2010infiltrating lymphocytes (TILs) in breast, endometrial, tubo\u2010ovarian, and vulvar cancer. Our analysis covers the relationship between TIL counts and density, immune cell subtype combinations, immunotherapy approaches, and patient outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      High TIL infiltration, especially CD8\n                      <jats:sup>+<\/jats:sup>\n                      T\u2010cells, generally correlates with improved outcomes such as in endometrial cancer (especially the\n                      <jats:italic>POLE<\/jats:italic>\n                      \u2010ultramutated subgroup), invasive breast cancer, and ovarian epithelial tumors. However, in ductal carcinoma in\u00a0situ (DCIS) of the breast, elevated TIL counts are linked to a worse prognosis. Ethnicity, the tumor microenvironment (TME), and molecular profiles further complicate the prognostic utility of TILs.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TIL\u2010based therapies have shown potential in personalized immunotherapy, particularly in recurrent, refractory ovarian cancer. Limited research on rarer gynecologic tumors hinders broader clinical applications.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71023","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T06:44:07Z","timestamp":1751870647000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Tumor\u2010Infiltrating Lymphocytes in Breast and Female Genital Tract Cancers: Overlooked Potential and Unexplored Frontiers"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3027-8164","authenticated-orcid":false,"given":"Kristijan","family":"Skok","sequence":"first","affiliation":[{"name":"Diagnostic and Research Institute of Pathology, Medical University of Graz  Graz Austria"},{"name":"Institute of Biomedical Sciences, Faculty of Medicine University of Maribor  Maribor Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Maccio","sequence":"additional","affiliation":[{"name":"Department of Pathology and Molecular Pathology University Hospital of Zurich  Zurich Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer D.","family":"Martin","sequence":"additional","affiliation":[{"name":"Department of Pathology and Laboratory Medicine University of British Columbia  Vancouver British Columbia Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Konstantin","family":"Br\u00e4utigam","sequence":"additional","affiliation":[{"name":"Centre for Evolution and Cancer Institute of Cancer Research  London UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_13_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2024.155775"},{"key":"e_1_2_13_3_1","doi-asserted-by":"publisher","DOI":"10.1093\/annonc\/mdu450"},{"key":"e_1_2_13_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.canlet.2025.217699"},{"key":"e_1_2_13_5_1","doi-asserted-by":"publisher","DOI":"10.1038\/nm.3394"},{"key":"e_1_2_13_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.adro.2018.08.018"},{"key":"e_1_2_13_7_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-019-0222-4"},{"key":"e_1_2_13_8_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41571-022-00620-6"},{"key":"e_1_2_13_9_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41416-022-02119-4"},{"issue":"6","key":"e_1_2_13_10_1","first-page":"6421","article-title":"Stromal and Intraepithelial Tumor\u2010Infiltrating Lymphocytes in Colorectal Carcinoma","volume":"14","author":"Jakubowska K.","year":"2017","journal-title":"Oncology Letters"},{"key":"e_1_2_13_11_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-022-00491-0"},{"key":"e_1_2_13_12_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41568-021-00339-z"},{"key":"e_1_2_13_13_1","doi-asserted-by":"publisher","DOI":"10.1007\/978-3-030-91311-3_3"},{"key":"e_1_2_13_14_1","doi-asserted-by":"publisher","DOI":"10.1038\/nature14001"},{"key":"e_1_2_13_15_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41422-020-0343-4"},{"key":"e_1_2_13_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/2162402X.2017.1364828"},{"key":"e_1_2_13_17_1","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-022-01229-0"},{"issue":"2","key":"e_1_2_13_18_1","first-page":"141","article-title":"Programmed Death Ligand\u20101 (PD\u2010L1) as a Predictive Marker for Immunotherapy in Solid Tumours: A Guide to Immunohistochemistry Implementation and Interpretation","volume":"53","author":"Paver E. 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