{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,2]],"date-time":"2026-09-02T17:50:23Z","timestamp":1788371423788,"version":"build-2803163510"},"reference-count":48,"publisher":"Wiley","issue":"13","license":[{"start":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T00:00:00Z","timestamp":1751846400000},"content-version":"vor","delay-in-days":6,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cancer cells exhibit significant heterogeneity, making their detection a challenging task.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>In this study, a unique Photonic Crystal Fiber (PCF) sensor with a circular core design and curved trapezoidal cladding is presented. It is especially designed to detect cancer cells efficiently.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      The proposed sensor demonstrates exceptional performance, achieving a maximum relative sensitivity (RS) of 99.71% for breast cancer type II cells, along with similarly high sensitivities for cervical, adrenal gland, skin, blood, and breast cancer type I cells. Key performance parameters highlight its accuracy in detecting cancer cells via minute changes in refractive index (RI), including ultra\u2010low confinement loss (CL) of up to 6.69\u2009\u00d7\u200910\n                      <jats:sup>\u221213<\/jats:sup>\n                      \u2009dB\/cm and effective material loss (EML) as low as 0.00161\u2009cm\n                      <jats:sup>\u22121<\/jats:sup>\n                      .\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The sensor's high accuracy, rapid response time, and ability to selectively target tumor cells make it a breakthrough in early cancer detection. Moreover, its compact size and potential for easy fabrication enhance its applicability in emergency settings. This cutting\u2010edge approach represents a major advancement in medical technology, paving the way for more efficient and targeted cancer diagnostics.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71024","type":"journal-article","created":{"date-parts":[[2025,7,7]],"date-time":"2025-07-07T05:22:33Z","timestamp":1751865753000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":17,"title":["Terahertz Photonic Crystal Fiber Sensor for Cancer Cell Detection: Performance Analysis and Discrimination"],"prefix":"10.1002","volume":"14","author":[{"given":"Kayab","family":"Khandakar","sequence":"first","affiliation":[{"name":"Electrical and Electronic Engineering Department Pabna University of Science and Technology  Pabna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Omar","family":"Faruk","sequence":"additional","affiliation":[{"name":"Electrical and Electronic Engineering Department Pabna University of Science and Technology  Pabna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3271-8630","authenticated-orcid":false,"given":"A. H. M. Iftekharul","family":"Ferdous","sequence":"additional","affiliation":[{"name":"Electrical and Electronic Engineering Department Pabna University of Science and Technology  Pabna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Md. Naimur Rahman","family":"Naim","sequence":"additional","affiliation":[{"name":"Electrical and Electronic Engineering Department Pabna University of Science and Technology  Pabna Bangladesh"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,7,7]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2018.100252"},{"key":"e_1_2_12_3_1","doi-asserted-by":"crossref","unstructured":"D. C.Allan J. A.West J. C.Fajardo M. T.Gallagher K. W.Koch andN. F.Borrelli \u201cPhotonic Crystal Fibers: Effective\u2010Index and Band\u2010Gap Guidance \u201dPhotonic Crystals and Light Localization in the 21st Century NATO Science Series vol. 563 pp. 305\u2013320. (2001) https:\/\/doi.org\/10.1007\/978\u201094\u2010010\u20100738\u20102_22.","DOI":"10.1007\/978-94-010-0738-2_22"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.dit.2013.03.009"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPROC.2007.900325"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1109\/LPT.2006.877220"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.2478\/jee\u20102023\u20100051"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.24425\/ijet.2023.146494"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.3390\/s151229891"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2023.2287691"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2018.04.022"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.2528\/PIERC22122503"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1080\/00268976.2024.2364042"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optlastec.2024.112197"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1364\/AO.529142"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1080\/02726343.2023.2244829"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cobme.2019.08.015"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604\u2010019\u20103773\u20102"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sintl.2020.100040"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ijleo.2014.08.018"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yofte.2015.04.006"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1364\/OE.23.032429"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.scitotenv.2020.142955"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0748\u20107983(98)91907\u20102"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/0168\u20109525(93)90209\u2010Z"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00339\u2010021\u201004785\u20102"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2020.100388"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10043\u2010021\u201000644\u2010w"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12596\u2010023\u201001423\u20103"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11082\u2010021\u201002818\u2010x"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12596\u2010023\u201001191\u20100"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11082\u2010023\u201004966\u20108"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.icheatmasstransfer.2024.107615"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1109\/JPHOT.2019.2924825"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2020.100335"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1109\/JSEN.2017.2775642"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.3390\/fib8100063"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.yofte.2019.101933"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2021.100438"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.optcom.2017.12.061"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aej.2023.01.002"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12633\u2010020\u201000696\u20108"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.sbsr.2020.100386"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11468\u2010020\u201001334\u20100"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11468\u2010021\u201001409\u20106"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.addma.2017.04.001"},{"key":"e_1_2_12_47_1","volume-title":"Sol\u2010Gel Derived Microstructured Fiber: Fabrication and Characterization, Optical Fiber Communication Conference","author":"Bise R. T.","year":"2005"},{"key":"e_1_2_12_48_1","doi-asserted-by":"publisher","DOI":"10.1364\/OME.4.001494"},{"key":"e_1_2_12_49_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.aca.2015.10.005"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71024","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71024","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71024","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T07:17:17Z","timestamp":1778915837000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71024"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":48,"journal-issue":{"issue":"13","published-print":{"date-parts":[[2025,7]]}},"alternative-id":["10.1002\/cam4.71024"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71024","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"2024-11-11","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-06-24","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-07","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71024"}}