{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T19:49:43Z","timestamp":1772999383983,"version":"3.50.1"},"reference-count":32,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"funder":[{"DOI":"10.13039\/501100017610","name":"Shenzhen Science and Technology Innovation Program","doi-asserted-by":"publisher","award":["20200713165429003"],"award-info":[{"award-number":["20200713165429003"]}],"id":[{"id":"10.13039\/501100017610","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2020A1515010148"],"award-info":[{"award-number":["2020A1515010148"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"publisher","award":["2021A1515110402"],"award-info":[{"award-number":["2021A1515110402"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Bladder cancer is the most common malignant tumor in the urinary system. The acquisition of urine samples has the advantages of being rapid and painless, and it can directly contact the lesions. It is an ideal source of non\u2010invasive tumor markers. The problems with urine markers are low specificity, the propensity for false positives or missed detections, and there is no unified diagnostic standard to measure the test results, which limits the clinical application of urine markers. In this study, we evaluate the diagnostic values of Cytokeratin 19 fragment (CYFRA21\u20101), Fibrin\/fibrinogen degradation products (FDP) and CYFRA21\u20101\u2009+\u2009FDP in bladder cancer, with the objective to expand the application scope of urinary tumor markers in the diagnosis of bladder cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We evaluated the performances of the CYFRA21\u20101 assay kit (electrochemiluminescence) and\/or FDP assay kit (electrochemiluminescence) in detecting bladder cancer. CYFRA21\u20101 and FDP levels were determined in urine samples from 467 participants in South China Hospital of Shenzhen University and Shenzhen Luohu People's Hospital. We performed performance validation of the CYFRA21\u20101 and FDP kits, established normal biological reference intervals, and finally analyzed the data to assess their diagnostic efficacies alone or in combination.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>The bladder cancer group had significantly higher urinary levels of CYFRA21\u20101 and FDP than the control group. The areas under the receiver operating characteristic curves (ROC\u2010AUCs) of CYFRA21\u20101, FDP, and CYFRA21\u20101\u2009+\u2009FDP were 0.929, 0.857, and 0.935, respectively, for discriminating bladder cancer cases from controls. The ROC\u2010AUC of CYFRA21\u20101 and FDP in combination was higher than that of any index alone.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Both CYFRA21\u20101 and FDP have good diagnostic values in predicting bladder cancer. In addition, combined detection of urinary CYFRA21\u20101 and FDP by electrochemiluminescence has better differentiation ability compared with each index alone and may be used for early screening and recurrence monitoring in bladder cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71056","type":"journal-article","created":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T12:32:34Z","timestamp":1754051554000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Diagnostic Values of Electrochemiluminescent Detection of Urinary CYFRA21\u20101 and FDP and Their Combined Detection in Bladder Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7542-6709","authenticated-orcid":false,"given":"Zhuoran","family":"Li","sequence":"first","affiliation":[{"name":"Department of Urology, Medical School, South China Hospital Shenzhen University  Shenzhen PR China"},{"name":"Shenzhen Luohu People's Hospital  Shenzhen PR China"},{"name":"Department of Central Laboratory Binzhou People's Hospital  Binzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xia","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School, South China Hospital Shenzhen University  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yamin","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Lifotronic Technology Co., Ltd.  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tao","family":"Huang","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School, South China Hospital Shenzhen University  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ning","family":"Yang","sequence":"additional","affiliation":[{"name":"Shenzhen Lifotronic Technology Co., Ltd.  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shannai","family":"Li","sequence":"additional","affiliation":[{"name":"Shenzhen Lifotronic Technology Co., Ltd.  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinyin","family":"Luo","sequence":"additional","affiliation":[{"name":"Shenzhen Lifotronic Technology Co., Ltd.  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaoyao","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Binzhou People's Hospital  Binzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Central Laboratory Binzhou People's Hospital  Binzhou PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3504-1630","authenticated-orcid":false,"given":"Song","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School, South China Hospital Shenzhen University  Shenzhen PR China"},{"name":"Shenzhen Luohu People's Hospital  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qifang","family":"Lei","sequence":"additional","affiliation":[{"name":"Department of Urology, Medical School, South China Hospital Shenzhen University  Shenzhen PR China"},{"name":"Shenzhen Luohu People's Hospital  Shenzhen PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,8,1]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21660"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1097\/CM9.0000000000002108"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2016.02.028"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.12.031"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00345-022-03943-2"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2020.08.016"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.2147\/OTT.S242778"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12885-022-09728-5"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11356-022-19617-w"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1080\/21691401.2019.1687491"},{"issue":"4","key":"e_1_2_12_12_1","first-page":"481","article-title":"New Diagnostic Tests for Urothelial Tumors of the Bladder","volume":"8","author":"Irani J.","year":"1998","journal-title":"Progr\u00e8s en Urologie"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000023329"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.02.007"},{"key":"e_1_2_12_15_1","doi-asserted-by":"crossref","DOI":"10.1177\/10760296211010973","article-title":"Hemostatic System (Fibrinogen Level, D\u2010Dimer, and FDP) in Severe and Non\u2010Severe Patients With COVID\u201019: A Systematic Review and Meta\u2010Analysis","volume":"27","author":"Rostami M.","year":"2021","journal-title":"Clinical and Applied Thrombosis\/Hemostasis"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0022-5347(01)64321-0"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cca.2012.08.018"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2005.03.014"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00604-022-05239-z"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.legalmed.2011.10.003"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.6004\/jnccn.2018.0072"},{"key":"e_1_2_12_22_1","first-page":"15","article-title":"Histological Typing of Urinary Bladder Tumors","volume":"10","author":"Mostofi F. 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