{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:36:49Z","timestamp":1786977409222,"version":"build-2736575974"},"reference-count":37,"publisher":"Wiley","issue":"14","license":[{"start":{"date-parts":[[2025,7,16]],"date-time":"2025-07-16T00:00:00Z","timestamp":1752624000000},"content-version":"vor","delay-in-days":15,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,7]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Stem\u2010cell mobilization in multiple myeloma is usually done with G\u2010CSF with or without Cyclophosphamide (Cy) based chemotherapy\/Plerixafor. Pre\u2010clinical data suggest the role of proteasome inhibitors in mobilization. We previously reported that Bortezomib (Bort) when added to a Cy\u2010based regimen had a better stem\u2010cell yield. Consequent to favorable results with Bort\u2009+\u2009Cy\u2010G\u2010CSF, we used Bortezomib with G\u2010CSF too. Hence, four different mobilization regimens were used\u2014Bort\u2009+\u2009G\u2010CSF (Group\u20101); G\u2010CSF\u2009+\u2009Plerixafor (Group\u20102); Bort\u2009\u2013\u2009Cy\u2010G\u2010CSF (Group\u20103); Cy\u2009+\u2009G\u2010CSF (Group\u20104). We report here our 15\u2010year retrospective analysis of these 4 mobilization regimens.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Objectives<\/jats:title>\n                    <jats:p>\n                      Primary objective was to determine proportion of patients with CD34\n                      <jats:sup>+<\/jats:sup>\n                      dose \u2265\u20095\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/kg in first apheresis in various groups. Secondary objectives were to determine median CD34\n                      <jats:sup>+<\/jats:sup>\n                      dose (\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      \/kg) in first apheresis, total median CD34\n                      <jats:sup>+<\/jats:sup>\n                      dose (\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      \/kg) of all harvests and frequency of mobilization failure. Mobilization failure was defined as total CD34\n                      <jats:sup>+<\/jats:sup>\n                      dose of &lt;\u20092\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      \/kg or abandoned harvest attempt at physician's discretion after anticipating a poor collection.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      All consecutive patients with MM aged 18\u201365\u2009years who underwent stem\u2010cell mobilization from September 2007\u2013December 2022 were included. In an intention\u2010to\u2010treat analysis, a total 200 patients with 205 mobilization attempts were analysed. The median age of the cohort was 48\u2009years. The percentage of patients who collected \u2265\u20095\u2009\u00d7\u200910\n                      <jats:sup>6<\/jats:sup>\n                      CD34\n                      <jats:sup>+<\/jats:sup>\n                      cells\/kg in the first apheresis was 26%, 53%, 69%, and 63% in Groups 1\u20134, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001). The median CD34 yield in the first harvest (\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      \/kg) was 3.62, 5.20, 6.04, and 6.05 in Groups 1\u20134, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.00004). The median total stem\u2010cell dose collected (\u00d710\n                      <jats:sup>6<\/jats:sup>\n                      \/kg) was 5.73, 6.17, 9.14, and 8.23 in Groups 1\u20134, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.00001). Mobilization failure rates were 7%, 3%, 0%, and 2%, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u2009NS).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Cyclophosphamide\u2010based chemo\u2010mobilization regimens with or without Bortezomib have the advantage of higher total stem\u2010cell yield, while they are equivalent to G\u2010CSF\u2009+\u2009Plerixafor for harvest in a single apheresis. The addition of Bortezomib to Cyclophosphamide may help to increase stem cell yield.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71068","type":"journal-article","created":{"date-parts":[[2025,7,17]],"date-time":"2025-07-17T02:11:04Z","timestamp":1752718264000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Moving Beyond G\u2010CSF Mobilization\u2014Learning From a 15\u2010Year Experience of Different Stem Cell Mobilization Regimens in Multiple Myeloma"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0642-2207","authenticated-orcid":false,"given":"Sumeet","family":"Mirgh","sequence":"first","affiliation":[{"name":"BMT Unit, Department of Medical Oncology Tata Memorial Centre, ACTREC  Navi Mumbai India"},{"name":"Homi Bhabha National Institute (HBNI)  Mumbai 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