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We calculated age\u2010adjusted incidence rates (IRs), incidence rate ratios (IRRs), and average annual percent changes (AAPCs) to compare incidence and temporal trends in PPAs and non\u2010PPAs in California by race\/ethnicity and sex. PPA was defined as areas with a poverty rate of 20% or more for approximately 30 continuous years.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Male patients in PPAs had significantly higher IRRs of colorectal, liver, lung, and stomach cancers, and female patients had higher cervical, kidney, liver, and stomach cancers. Across all racial\/ethnic groups, cervical and liver cancer IRRs were significantly higher, and IRRs for female breast cancer were lower in PPAs. The incidence of several cancers significantly decreased over time only in non\u2010PPAs. Colorectal cancer and non\u2010Hodgkin lymphoma among Hispanic residents significantly increased in PPAs (AAPC\u2009=\u20090.4, 1.2) and colorectal cancer decreased only in non\u2010PPAs (AAPC\u2009=\u2009\u22121.4). Thyroid cancer among non\u2010Hispanic Black residents increased only in PPAs (AAPC\u2009=\u20094.7).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our findings highlight race\/ethnicity and sex disparities in cancer incidence and temporal trends for PPA residents. Further research is needed to understand the specific etiological factors underlying these disparities, and to support the development of public health policies and initiatives to decrease the cancer burden in California.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71088","type":"journal-article","created":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T12:10:31Z","timestamp":1753877431000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Cancer Incidence and Trends in Persistent Poverty Areas of California by Race\/Ethnicity and Sex"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9624-6635","authenticated-orcid":false,"given":"Ani S.","family":"Movsisyan Vernon","sequence":"first","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8490-6229","authenticated-orcid":false,"given":"Frances B.","family":"Maguire","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ayman T.","family":"Ullah","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brenda M.","family":"Hofer","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Arti","family":"Parikh\u2010Patel","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ted","family":"Wun","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shehnaz K.","family":"Hussain","sequence":"additional","affiliation":[{"name":"UC Davis Health University of California Davis Comprehensive Cancer Center  Sacramento California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Theresa H. 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