{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,30]],"date-time":"2025-07-30T08:06:54Z","timestamp":1753862814305,"version":"3.41.2"},"reference-count":37,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T00:00:00Z","timestamp":1711756800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071898"],"award-info":[{"award-number":["82071898"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2024,4]]},"abstract":"<jats:title>Abstract<\/jats:title><jats:sec><jats:title>Background<\/jats:title><jats:p>The value of SyMRI\u2010derived parameters from lumbar marrow for predicting early treatment response and optimizing the risk stratification of the Revised International Staging System (R\u2010ISS) in participants with multiple myeloma (MM) is unknown.<\/jats:p><\/jats:sec><jats:sec><jats:title>Methods<\/jats:title><jats:p>We prospectively enrolled participants with newly diagnosed MM before treatment. The SyMRI of lumbar marrow was used to calculate T1, T2, and PD values and the clinical features were collected. All participants were divided into good response (\u2265VGPR) and poor response (&lt;VGPR) groups after four treatment cycles. Univariate, multivariate analyses and ROC were used to identify prognostic significance. Mann\u2013Whitney <jats:italic>U<\/jats:italic>\u2010tests were used to compare the SyMRI parameters between genders. The value of optimizing the risk stratification was analyzed by Fisher's exact tests at each R\u2010ISS stage.<\/jats:p><\/jats:sec><jats:sec><jats:title>Results<\/jats:title><jats:p>Fifty\u2010nine participants (good response, <jats:italic>n<\/jats:italic>\u2009=\u200933; poor response, <jats:italic>n<\/jats:italic>\u2009=\u200926) were evaluated. The bone marrow plasma cell percentage, \u03b2<jats:sub>2<\/jats:sub>\u2010microglobulin, T1 and T2 value were difference between two groups (all <jats:italic>p<\/jats:italic>\u2009&lt;\u20090.05). The T1 (odds ratio 1.003, <jats:italic>p<\/jats:italic>\u2009=\u20090.005) and T2 values (odds ratio 0.910, <jats:italic>p<\/jats:italic>\u2009=\u20090.002) were independent predictors and the AUC and cut\u2010off values were 0.787, 967.2\u2009ms and 0.784, 75.9\u2009ms, respectively. There were no significant differences in SyMRI parameters between genders. Participants with both T1 value \u2265967.2\u2009ms and T2 value \u226475.9\u2009ms in the R\u2010ISS II stage were potentially to get poor response.<\/jats:p><\/jats:sec><jats:sec><jats:title>Conclusions<\/jats:title><jats:p>Synthetic MRI is a promising tool for predicting early treatment response to MM and promoting R\u2010ISS II stage risk stratification.<\/jats:p><\/jats:sec>","DOI":"10.1002\/cam4.7109","type":"journal-article","created":{"date-parts":[[2024,3,30]],"date-time":"2024-03-30T08:09:32Z","timestamp":1711786172000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["The quantitative parameters based on marrow metabolism derived from synthetic <scp>MRI<\/scp>: A pilot study of prognostic value in participants with newly diagnosed multiple myeloma"],"prefix":"10.1002","volume":"13","author":[{"given":"Sha","family":"Cui","sequence":"first","affiliation":[{"name":"Department of Medical Imaging Shanxi Medical University  Taiyuan China"},{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yinnan","family":"Guo","sequence":"additional","affiliation":[{"name":"Department of Pain Fifth Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiran","family":"Niu","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianting","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjin","family":"Bian","sequence":"additional","affiliation":[{"name":"Department of Medical Imaging Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenqi","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wenjia","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Qian","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Wang","sequence":"additional","affiliation":[{"name":"Department of Radiology Second Hospital of Shanxi Medical University  Taiyuan 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