{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T06:06:56Z","timestamp":1789452416469,"version":"build-2803163510"},"reference-count":45,"publisher":"Wiley","issue":"15","license":[{"start":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T00:00:00Z","timestamp":1754092800000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"http:\/\/doi.wiley.com\/10.1002\/tdm_license_1.1"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,8]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Radical cystectomy (RC) is a standard\u2010of\u2010care treatment for muscle\u2010invasive bladder cancer (MIBC). However, there is a lack of data comparing the benefit of robot\u2010assisted radical cystectomy (RARC) with laparoscopic radical cystectomy (LRC) or open radical cystectomy (ORC) in Japan. We aimed to explore the safety of RARC compared with that of LRC or ORC using the Japanese National Clinical Database (NCD).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This retrospective study reviewed the data of 17,549 patients with MIBC who underwent radical cystectomy between February 2019 and December 2022 in the Japanese NCD. We compared the postoperative complications within 30\u2009days between the surgical procedures using the Clavien\u2013Dindo classification. Multivariable logistic regression analysis was conducted for grade \u2265\u20093 postoperative complications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Overall, 8308, 3101, and 6140 patients underwent RARC, LRC, and ORC, respectively. The rates of any grade and grade \u2265\u20093 postoperative complications within 30\u2009days were significantly lower in the RARC group than in the ORC group. RARC had no significant difference in grade \u2265\u20093 postoperative complications in the ileal neobladder. Regarding any grade postoperative complications, RARC had a significantly lower rate of delirium, surgical site infection, sepsis, and gastrointestinal tract leakage than ORC. Multivariable logistic regression analysis revealed that the incidence of grade \u2265\u20093 postoperative complications was significantly lower in RARC (odds ratio, 0.83; 95% confidence interval, 0.72\u20130.95).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>RARC had a lower complication rate compared with ORC. LRC had comparable outcomes to RARC. The findings of this study contribute to RARC as being the standard treatment for MIBC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71109","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T08:03:24Z","timestamp":1754121804000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Safety of Robot\u2010Assisted Radical Cystectomy for Muscle\u2010Invasive Bladder Cancer: A Real\u2010World Analysis Using the National Clinical Database in Japan"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0026-4079","authenticated-orcid":false,"given":"Shingo","family":"Hatakeyama","sequence":"first","affiliation":[{"name":"National Clinical Database Steering Committee of Japanese Urological Association  Tokyo Japan"},{"name":"Department of Urology Hirosaki University Graduate School of Medicine  Hirosaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3337-7595","authenticated-orcid":false,"given":"Hiroyuki","family":"Yamamoto","sequence":"additional","affiliation":[{"name":"National Clinical Database Steering Committee of Japanese Urological Association  Tokyo Japan"},{"name":"Department of Healthcare Quality Assessment, Graduate School of Medicine The University of Tokyo  Tokyo Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Kitamura","sequence":"additional","affiliation":[{"name":"National Clinical Database Steering Committee of Japanese Urological Association  Tokyo Japan"},{"name":"Faculty of Medicine, Department of Urology University of Toyama  Toyama Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiyuki","family":"Kamoto","sequence":"additional","affiliation":[{"name":"National Clinical Database Steering Committee of Japanese Urological Association  Tokyo Japan"},{"name":"Faculty of Medicine, Department of Urology University of Miyazaki  Miyazaki Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1624-6676","authenticated-orcid":false,"given":"Eiji","family":"Kikuchi","sequence":"additional","affiliation":[{"name":"National Clinical Database Steering Committee of Japanese Urological Association  Tokyo Japan"},{"name":"Department of Urology St. Marianna University School of Medicine  Kawasaki Kanagawa Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2020.03.055"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14210"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.1997"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.08.016"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.14281"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2018.04.030"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15250"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15382"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15377"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15447"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0140\u20106736(18)30996\u20106"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2023.04.004"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1111\/dom.14074"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1161\/circgen.119.002670"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.70032"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.70033"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00595\u2010018\u20101700\u20105"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15561"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1111\/iju.15551"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euf.2017.12.011"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00464\u2010024\u201011103\u20103"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1007\/s10147\u2010016\u20100950\u20108"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2021.08.027"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1177\/15579883241274866"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1111\/bju.16565"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.12.007"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.3390\/jcm13082421"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1097\/ju.0000000000000565"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2021.10.012"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1007\/s11701\u2010024\u201002026\u20101"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2024.1435050"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.07.038"},{"key":"e_1_2_12_34_1","doi-asserted-by":"publisher","DOI":"10.1136\/bmjopen\u20102020\u2010043266"},{"key":"e_1_2_12_35_1","doi-asserted-by":"publisher","DOI":"10.5489\/cuaj.2069"},{"key":"e_1_2_12_36_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urology.2020.08.038"},{"key":"e_1_2_12_37_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.euo.2023.01.002"},{"key":"e_1_2_12_38_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0286264"},{"key":"e_1_2_12_39_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12894\u2010019\u20100533\u2010x"},{"key":"e_1_2_12_40_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2014.01.029"},{"key":"e_1_2_12_41_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamanetworkopen.2023.17255"},{"key":"e_1_2_12_42_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.hlpt.2018.10.008"},{"key":"e_1_2_12_43_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0270368"},{"key":"e_1_2_12_44_1","doi-asserted-by":"publisher","DOI":"10.1093\/jjco\/hyae039"},{"key":"e_1_2_12_45_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.urolonc.2025.03.002"},{"key":"e_1_2_12_46_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.eururo.2015.02.003"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71109","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/full-xml\/10.1002\/cam4.71109","content-type":"application\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71109","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T17:12:59Z","timestamp":1772989979000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71109"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":45,"journal-issue":{"issue":"15","published-print":{"date-parts":[[2025,8]]}},"alternative-id":["10.1002\/cam4.71109"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71109","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"2025-02-21","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-07-20","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71109"}}