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However, some patients stop treatment early because of AI\u2010associated musculoskeletal symptoms (AIMSS). AIMSS is due in part to systemic inflammation. Cannabidiol (CBD) has anti\u2010nociceptive and anti\u2010inflammatory properties, making it a potential treatment option for AIMSS.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>\n                      Women with stage 0\u20133 hormone receptor\u2010positive breast cancer experiencing AIMSS enrolled in this phase 2 clinical trial. Patients received CBD (Epidiolex), titrated over 4\u2009weeks to 100\u2009mg BID, for a total of 15\u2009weeks. Patient\u2010reported outcomes were collected serially. The primary endpoint was the number of patients with at least a 2\u2010point reduction in worst pain from baseline to 15\u2009weeks. Statistical analysis was completed using paired\n                      <jats:italic>t<\/jats:italic>\n                      \u2010tests and linear mixed models.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Of 39 eligible patients, 28 completed protocol\u2010directed study treatment. Eleven discontinued treatment due to toxicity (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20095) or per patient preference (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u20096). Seventeen of 39 patients met the primary endpoint (43.6%, 95% CI [28%, 60%]). Worst pain improved 0.13 per week of treatment (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001) for all patients; average improvement in worst pain was 1.95 points at the end of 15\u2009weeks. Of the 28 patients who completed the study, average reduction in worst pain was 2.36 points (95% CI [\u22123.22, \u22121.49]) between baseline and Week 15.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Treatment with CBD was safe, tolerable, and associated with improvement in joint pain for a subset of patients. Additional studies are needed to further understand the impact of CBD on AIMSS and which patients are most likely to benefit from CBD treatment.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Trial Registration<\/jats:title>\n                    <jats:p>\n                      <jats:ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"http:\/\/www.clinicaltrials.gov\">www.clinicaltrials.gov<\/jats:ext-link>\n                      : NCT04754399\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71117","type":"journal-article","created":{"date-parts":[[2025,8,2]],"date-time":"2025-08-02T04:54:51Z","timestamp":1754110491000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Pilot Study of Cannabidiol for Treatment of Aromatase Inhibitor\u2010Associated Musculoskeletal Symptoms in Breast Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9268-7070","authenticated-orcid":false,"given":"Nicole M. G.","family":"Fleege","sequence":"first","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elise A.","family":"Miller","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelley M.","family":"Kidwell","sequence":"additional","affiliation":[{"name":"Department of Biostatistics University of Michigan School of Public Health  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zeb R.","family":"Zacharias","sequence":"additional","affiliation":[{"name":"Human Immunology Core Holden Comprehensive Cancer Center  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5307-9854","authenticated-orcid":false,"given":"Jon","family":"Houtman","sequence":"additional","affiliation":[{"name":"Human Immunology Core Holden Comprehensive Cancer Center  Iowa City Iowa USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kelly","family":"Scheu","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kathleen","family":"Kemmer","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kevin F.","family":"Boehnke","sequence":"additional","affiliation":[{"name":"University of Michigan Medical School  Ann Arbor Michigan USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4771-5930","authenticated-orcid":false,"given":"N. 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