{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,11]],"date-time":"2026-10-11T00:19:45Z","timestamp":1791677985963,"version":"4.3.4"},"reference-count":26,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T00:00:00Z","timestamp":1757721600000},"content-version":"vor","delay-in-days":12,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Neoadjuvant therapy followed by surgery is preferred for locally advanced esophageal squamous cell carcinoma (ESCC), but the necessity of adjuvant therapy remains controversial. Tumor regression grade (TRG) reflects the response to neoadjuvant therapy and may predict patient prognosis, yet its role in guiding adjuvant therapy remains unexplored. This study aimed to explore the role of TRG and other clinical characteristics in predicting the efficacy of postoperative adjuvant therapy in ESCC patients receiving neoadjuvant therapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This study included patients who underwent R0 esophagectomy for thoracic ESCC after neoadjuvant therapy between January 2016 and December 2021 across three high\u2010volume centers. Patients were assessed by TRG and divided into good responders (TRG 0\u20131) and poor responders (TRG 2\u20133).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Among 416 patients with a median follow\u2010up of 52\u2009months, adjuvant therapy extended median survival by 8\u2009months, which was statistically insignificant (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.28). In the TRG 0\u20131 subgroup, those receiving adjuvant therapy had 3\u2010year and 5\u2010year OS rates of 94.6% and 86.8%, compared to 78.8% and 71.6% for the observation group (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.02). Multivariable Cox regression showed adjuvant therapy was associated with reduced mortality in the TRG 0\u20131 (HR 0.32; 95% CI 0.14\u20130.73;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.006), positive lymph nodes (HR 0.53; 95% CI 0.36\u20130.78;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.001), and ypT3\u20104 subgroups (HR 0.63; 95% CI 0.43\u20130.92;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.017).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>TRG is a promising predictor of the prognostic value of adjuvant therapy in ESCC patients. Patients with a good TRG response, positive lymph nodes, and ypT3\u20104 stage benefit from adjuvant therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71166","type":"journal-article","created":{"date-parts":[[2025,9,13]],"date-time":"2025-09-13T08:14:17Z","timestamp":1757751257000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Tumor Regression Grade as a Predictor of Adjuvant Therapy Benefits in Esophageal Squamous Cell Carcinoma Patients After Neoadjuvant Therapy"],"prefix":"10.1002","volume":"14","author":[{"given":"Yizhou","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Key Laboratory of Cardio\u2010Thoracic Surgery (Fujian Medical University), Fujian Province University  Fuzhou China"},{"name":"National key Clinical Specialty of Thoracic Surgery  Fuzhou China"},{"name":"Clinical 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Fuzhou China"},{"name":"Clinical Research Center for Thoracic Tumors of Fujian Province  Fuzhou China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bingqiang","family":"Cai","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery The First Affiliated Hospital of Xiamen University  Xiamen China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongcong","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Quanzhou First Hospital  Fujian China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chuanquan","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Thoracic Surgery Fujian Medical University Union Hospital  Fuzhou China"},{"name":"Key Laboratory of Cardio\u2010Thoracic Surgery (Fujian Medical University), Fujian Province University  Fuzhou China"},{"name":"National key Clinical Specialty of Thoracic Surgery  Fuzhou China"},{"name":"Clinical 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