{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:53:19Z","timestamp":1787500399378,"version":"build-2736575974"},"reference-count":54,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T00:00:00Z","timestamp":1756339200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071401"],"award-info":[{"award-number":["82071401"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Pancreatic cancer (PC) is a common malignant tumor with high morbidity and mortality and a very poor prognosis, highlighting the urgent need to identify molecular therapeutic targets. Monocyte chemotactic protein\u2010inducible protein\u20101 (MCPIP1) is a common inflammatory protein associated with the pathogenesis of a variety of cancers, although a comprehensive understanding of its function and the underlying mechanisms involved in PC remains unclear.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Materials and Methods<\/jats:title>\n                    <jats:p>Immunohistochemistry, western blotting, immunofluorescence, flow cytometry, Transwell, and the scratch assay were used to evaluate the functional role of MCPIP1 in PC. Human PC samples, PC cells, and tumor tissues from subcutaneous tumors of nude mice were examined for MCPIP1 and a panel of epithelial\u2010mesenchymal transition (EMT) \u2010related indicators. In the mechanistic study, the IL6\/JAK\/STAT3 signaling pathway was investigated as a potential downstream pathway. IL6 activity was inhibited using the pharmacological inhibitor LMT\u201028 and was applied to MCPIP1 gene\u2010deficient cells to assess the reversal of the malignant phenotype.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>MCPIP1 was significantly downregulated in PC tissues and its expression strongly correlated with patient survival. MCPIP1 knockdown enhanced tumor cell stemness, proliferation, migration, and hybrid epithelial\u2010mesenchymal transition (hybrid EMT) in PC cell lines, whereas overexpression suppressed these phenotypes. In xenograft models, MCPIP1 knockdown promoted tumor growth and hybrid EMT progression in mice. MCPIP1 knockdown activated the IL6\/JAK\/STAT3 signaling pathway, which was inhibited by MCPIP1 overexpression. LMT\u201028 treatment reversed the stemness and hybrid EMT phenotypes of MCPIP1\u2010deficient cells.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>MCPIP1 is a key regulator of PC progression, acting as a tumor suppressor by inhibiting the IL6\/JAK\/STAT3 signaling pathway. The findings suggest that MCPIP1 is a promising therapeutic target with potential implications for the development of new strategies for managing PC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71179","type":"journal-article","created":{"date-parts":[[2025,8,28]],"date-time":"2025-08-28T11:58:38Z","timestamp":1756382318000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["<scp>MCPIP1<\/scp>\n                    Controls Hybrid\n                    <scp>EMT<\/scp>\n                    and Tumor Stemness via the\n                    <scp>IL6<\/scp>\n                    \/\n                    <scp>JAK2<\/scp>\n                    \/\n                    <scp>STAT3<\/scp>\n                    Axis in Pancreatic Cancer"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0005-9285-2095","authenticated-orcid":false,"given":"Xihui","family":"Ding","sequence":"first","affiliation":[{"name":"Department of Anatomy Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Zheng","sequence":"additional","affiliation":[{"name":"Department of Anatomy Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Anatomy Anhui Medical University  Hefei Anhui China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fu","family":"Lai","sequence":"additional","affiliation":[{"name":"Department of Anatomy Anhui Medical University  Hefei Anhui 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