{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T01:29:57Z","timestamp":1792718997635,"version":"4.5.0"},"reference-count":32,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>This study presents the outcomes of high\u2010risk group retinoblastoma (Rb) patients enrolled in the AIEOP RTB 012 Protocol.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with intraocular unilateral Rb classified as group C\/D according to \u201cInternational Intraocular Retinoblastoma Classification\u201d (IIRC), as well as those with bilateral Rb with at least one eye group C\/D\/E\u2010IIRC, were treated with four cycles of carboplatin\/etoposide combined with focal treatments.<\/jats:p>\n                    <jats:p>The primary endpoint was to evaluate ocular event\u2010free survival (EFS) and overall survival (OS), where events were defined as the need for radiotherapy, eye enucleation, and second\u2010line treatment. Visual acuity (VA) was assessed in all available cases.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Between February 2012 and September 2017, 60 patients were enrolled (88 eyes), 32 unilateral Rb, 28 bilateral. Twelve eyes were classified as group A\/B, 15 group C, 40 group D, and 21 group E. At a median follow\u2010up of 8.71\u2009years, 42\/88 eyes were preserved. The 2\u2010 and 5\u2010year eye EFS rates were 31.1% (95% CI: 24.4\u201344.0) and 29.5% (95% CI: 20.4\u201339.2), respectively. The corresponding 2\u2010 and 5\u2010year eye OS rates were 63.3% (95% CI: 52.7\u201372.7) and 48.9% (95% CI: 38.1\u201358.8). Ocular survival significantly differed across IIRC groups, with 2\u2010 and 5\u2010year survival rates of 100% for group A\/B, 86.7% and 73.3% for group C, 65% and 42.5% for group D, and 23.8% and 14.3% for group E, respectively (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05). No severe toxicity was reported. Among 28 bilateral Rb patients, 12 had VA of at least 20\/30 according to the Snellen chart.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>The AIEOP RTB 012 protocol has proven to be both safe and effective, ensuring a favorable final VA.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71188","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T11:24:29Z","timestamp":1756812269000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Eye Salvage and Vision Preservation in High\u2010Risk Intraocular Retinoblastoma Patients: Long\u2010Term Results From the Prospective Phase II AIEOP RTB 012 Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7030-8639","authenticated-orcid":false,"given":"Ida","family":"Russo","sequence":"first","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valentina","family":"Di Ruscio","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Antonietta","family":"De Ioris","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giada","family":"Del Baldo","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Debora","family":"De Pasquale","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Valente","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Bambino Ges\u00f9 IRCCS Children's Hospital  Passoscuro, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrico","family":"Opocher","sequence":"additional","affiliation":[{"name":"Hematology Oncology Division, Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Parrozzani","sequence":"additional","affiliation":[{"name":"Department of Ophthalmology University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Di Giannatale","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria Giuseppina","family":"Cefalo","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annalisa","family":"Serra","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe Maria","family":"Milano","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Longo","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessia","family":"Carboni","sequence":"additional","affiliation":[{"name":"Neuroradiology Unit \u201cBambino Ges\u00f9\u201d Children's Hospital IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"De Vito","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories Bambino Gesu Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianluigi","family":"Natali","sequence":"additional","affiliation":[{"name":"Interventional Radiology Unit, Department of Surgery Bambino Ges\u00f9 Children's Hospital  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gemma","family":"D'Elia","sequence":"additional","affiliation":[{"name":"Laboratory of Medical Genetics, Molecular Genetics Unit Bambino Ges\u00f9 Children Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gianni","family":"Bisogno","sequence":"additional","affiliation":[{"name":"Hematology Oncology Division, Department of Women's and Children's Health University of Padua  Padua Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angela","family":"Mastronuzzi","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raffaele","family":"Cozza","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rita","family":"Alaggio","sequence":"additional","affiliation":[{"name":"Pathology Unit, Department of Laboratories Bambino Gesu Children's Hospital, IRCCS  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonino","family":"Romanzo","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Bambino Ges\u00f9 IRCCS Children's Hospital  Passoscuro, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Buzzonetti","sequence":"additional","affiliation":[{"name":"Ophthalmology Unit Bambino Ges\u00f9 IRCCS Children's Hospital  Passoscuro, Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franco","family":"Locatelli","sequence":"additional","affiliation":[{"name":"Onco\u2010Hematology, Cell Therapy, Gene Therapies and Hemopoietic Transplant Bambino Ges\u00f9 Children's Hospital, IRCCS  Rome Italy"},{"name":"Department of Life Sciences and Public Health Catholic University of the Sacred Heart  Rome Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102020\u2010316613"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442\u20109071.2010.02297.x"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000091"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1996.01100140548005"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(97)30053-0"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2000.18.1.12"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ohc.2004.11.003"},{"key":"e_1_2_12_9_1","unstructured":"National Cancer Institute \u201cCommon Terminology Criteria for Adverse Events (CTCAE) Version 4.0 \u201d(2009) https:\/\/evs.nci.nih.gov\/ftp1\/CTCAE\/About.html."},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1016\/s0031\u20103955(16)36251\u20104"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.39.1110"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2006.06.018"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13092216"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1055\/a\u20102237\u20102943"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.17219\/acem\/166664"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102011\u2010301016"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2020.09.006"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol\u20102013\u2010303694"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.4103\/joco.joco_323_21"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28721"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.05.007"},{"key":"e_1_2_12_22_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.21.02337"},{"key":"e_1_2_12_23_1","doi-asserted-by":"publisher","DOI":"10.1186\/s40942\u2010017\u20100093\u20108"},{"key":"e_1_2_12_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejmg.2022.104674"},{"key":"e_1_2_12_25_1","doi-asserted-by":"publisher","DOI":"10.1038\/s41467\u2010021\u201025792\u20100"},{"key":"e_1_2_12_26_1","doi-asserted-by":"publisher","DOI":"10.1038\/s42003-024-06596-6"},{"key":"e_1_2_12_27_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMra1803083"},{"key":"e_1_2_12_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330\u2010023\u201010054\u2010y"},{"key":"e_1_2_12_29_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaophthalmol.2023.6516"},{"key":"e_1_2_12_30_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.222264"},{"key":"e_1_2_12_31_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28963"},{"key":"e_1_2_12_32_1","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.28158"},{"key":"e_1_2_12_33_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2011.36.9744"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71188","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:32:10Z","timestamp":1761129130000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71188"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":32,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cam4.71188"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71188","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-06-22","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-21","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-02","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71188"}}