{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T18:36:58Z","timestamp":1780339018460,"version":"3.54.1"},"reference-count":39,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T00:00:00Z","timestamp":1757289600000},"content-version":"vor","delay-in-days":7,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["5R01DA039192\u201008"],"award-info":[{"award-number":["5R01DA039192\u201008"]}],"id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004917","name":"Cancer Prevention and Research Institute of Texas","doi-asserted-by":"publisher","award":["RP210130"],"award-info":[{"award-number":["RP210130"]}],"id":[{"id":"10.13039\/100004917","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Introduction<\/jats:title>\n                    <jats:p>Chronic pain is a major but modifiable contributor to poor quality of life among long\u2010term cancer survivors. With growing concern over opioid\u2010related risks, gabapentinoids have emerged as a safer alternative, though evidence comparing their effectiveness remains limited.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We conducted a retrospective cohort study using SEER\u2010MHOS linked data (1998\u20132021) to examine pain interference and health\u2010related quality of life (HRQoL) among 24,651 cancer survivors. Participants were categorized as opioid\u2010only (OPIOID\u2010only), gabapentinoid\u2010only (GABA\u2010only), both (BOTH), or no medication (NONE). Changes in pain interference and Physical and Mental Component Summary scores (PCS, MCS) were analyzed using paired t\u2010tests and multivariate regression, adjusting for demographic and clinical covariates.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Over a 1 to 3\u2009year follow\u2010up, all groups showed increased pain interference and declines in PCS and MCS scores. PCS declined by \u22121.01 in the OPIOID\u2010only group and \u22121.06 in the GABA\u2010only group. The BOTH group had stable PCS (+0.06) and a modest improvement in pain interference (\u22120.07). Multivariate models showed no significant difference between OPIOID\u2010only and GABA\u2010only for pain interference or PCS, but the BOTH group had significantly less pain worsening (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.0001) and PCS decline (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.004).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Gabapentinoids demonstrate comparable effectiveness as opioids for pain and HRQoL in cancer survivors, supporting their use as a safer alternative. Combination therapy showed better physical function and pain control, but findings may reflect higher baseline comorbidity and limited decline capacity rather than true superiority. These results underscored the need for personalized, multimodal pain management and further research on the long\u2010term safety of combination therapy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71189","type":"journal-article","created":{"date-parts":[[2025,9,8]],"date-time":"2025-09-08T10:35:57Z","timestamp":1757327757000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Comparative Effectiveness of Opioids and Opioid Substitutes on Pain and Health Related Quality of Life Among Cancer Survivors"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0009-3866-9221","authenticated-orcid":false,"given":"Shirley K.","family":"Chan Sanchez","sequence":"first","affiliation":[{"name":"John Sealy School of Medicine University of Texas Medical Branch  Galveston Texas USA"},{"name":"School of Public and Population Health University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6937-3507","authenticated-orcid":false,"given":"Samuel V.","family":"David","sequence":"additional","affiliation":[{"name":"Office of Biostatistics, Department of Biostatistics &amp; Data Science University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6126-6465","authenticated-orcid":false,"given":"Efstathia","family":"Polychronopoulou","sequence":"additional","affiliation":[{"name":"Office of Biostatistics, Department of Biostatistics &amp; Data Science University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7460-7281","authenticated-orcid":false,"given":"Mukaila","family":"Raji","sequence":"additional","affiliation":[{"name":"Division of Geriatric Medicine, Department of Internal Medicine University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1927-0927","authenticated-orcid":false,"given":"Yong\u2010Fang","family":"Kuo","sequence":"additional","affiliation":[{"name":"Department of Biostatistics &amp; Data Science, School of Public and Population Health University of Texas Medical Branch  Galveston Texas USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,8]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"Cancer treatment and survivorship statistics \u201cMiller \u2010 2022 \u2010 CA: A Cancer Journal for Clinicians \u2010 Wiley Online Library \u201d(2022) accessed April 28 2025 https:\/\/acsjournals.onlinelibrary.wiley.com\/doi\/full\/10.3322\/caac.21731."},{"key":"e_1_2_11_3_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.21871"},{"key":"e_1_2_11_4_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2013.52.4629"},{"key":"e_1_2_11_5_1","unstructured":"Update on Prevalence of Pain in Patients With Cancer: Systematic Review and Meta\u2010Analysis accessed April 28 2025 https:\/\/pubmed.ncbi.nlm.nih.gov\/27112310\/."},{"key":"e_1_2_11_6_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(12)70040\u20102"},{"key":"e_1_2_11_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s12094\u2010016\u20101529\u20106"},{"key":"e_1_2_11_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2016.68.5206"},{"key":"e_1_2_11_9_1","doi-asserted-by":"publisher","DOI":"10.1002\/cam4.3709"},{"key":"e_1_2_11_10_1","doi-asserted-by":"publisher","DOI":"10.1111\/jgs.15945"},{"key":"e_1_2_11_11_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2017.74.1363"},{"key":"e_1_2_11_12_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.18.00938"},{"key":"e_1_2_11_13_1","doi-asserted-by":"publisher","DOI":"10.2147\/SAR.S85409"},{"key":"e_1_2_11_14_1","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/djz233"},{"key":"e_1_2_11_15_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30839"},{"key":"e_1_2_11_16_1","doi-asserted-by":"publisher","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"e_1_2_11_17_1","unstructured":"M.MusumeciandJ. 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