{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T17:09:25Z","timestamp":1792084165467,"version":"4.4.0"},"reference-count":20,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T00:00:00Z","timestamp":1756425600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>The surgical indications for follicular thyroid neoplasms (FTNs) remain controversial due to challenges in the preoperative follicular thyroid carcinoma (FTC) diagnosis. We aimed to explore the sonographic features of the FTN capsule and establish a prediction model for diagnosing FTC without high\u2010risk features.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This prospective cohort study enrolled consecutive adult patients with FTN. Patients presenting with extrathyroidal extension or extracapsular angioinvasion on preoperative imaging were excluded. Intraoperative ultrasound (US)\u2010guided incisions were conducted in 20 patients during thyroidectomy. Sonographic features of FTN capsules were identified and validated through comparison with US, macroscopic, and microscopic pathology images from the same US\u2010selected section. Invaded capsules were categorized based on pathological indicators of capsular invasion. The diagnostic performance of the US capsule\u2010based model and US risk stratification systems (American College of Radiology Thyroid Imaging Reporting and Data System [ACR\u2010TIRADS] and Ultrasound Follicular Thyroid Imaging Reporting and Data System [F\u2010TIRADS]) were compared.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Seventy\u2010four patients with unifocal lesions and 14 patients with multifocal lesions were enrolled and pathologically diagnosed with follicular thyroid adenoma (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200967) and FTC (\n                      <jats:italic>n<\/jats:italic>\n                      \u2009=\u200935). As widely invasive FTC was initially excluded, there were 34 minimally invasive subtypes and 1 encapsulated angioinvasive subtype. The areas under the curves for the US capsule\u2010based model, ACR\u2010TIRADS, and F\u2010TIRADS were 0.839 (95% confidence interval [CI], 0.753\u20130.904), 0.852 (95% CI, 0.768\u20130.914), and 0.840 (95% CI, 0.755\u20130.905), respectively. No significant differences were observed in the areas under the curves, sensitivity, or accuracy of the US capsule\u2010based model, ACR\u2010TIRADS, and F\u2010TIRADS. The specificities of the US capsule\u2010based model and F\u2010TIRADS were higher than that of the ACR\u2010TIRADS (88.1% and 80.60%, respectively, vs. 44.8%,\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.05).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Careful US scanning enables clear FTN capsule visualization, providing a straightforward, specific method for diagnosing FTC and guiding completion thyroidectomy by detecting intracapsular angioinvasion in patients with FTC.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71190","type":"journal-article","created":{"date-parts":[[2025,8,29]],"date-time":"2025-08-29T11:15:22Z","timestamp":1756466122000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Prospective Validation of an Ultrasound Capsule\u2010Based Model for Predicting Follicular Thyroid Carcinoma Without High\u2010Risk Features"],"prefix":"10.1002","volume":"14","author":[{"given":"Xiang\u2010yun","family":"Yao","sequence":"first","affiliation":[{"name":"Department of Ultrasound Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xin","family":"Li","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fang","family":"Mei","sequence":"additional","affiliation":[{"name":"Department of Pathology Peking University Third Hospital, School of Basic Medical Sciences, Peking University Health Science Center  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shi\u2010bing","family":"Song","sequence":"additional","affiliation":[{"name":"Department of General Surgery Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li\u2010gang","family":"Cui","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-2444-5354","authenticated-orcid":false,"given":"Shi","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Ultrasound Peking University Third Hospital  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,8,29]]},"reference":[{"key":"e_1_2_12_2_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.asjsur.2024.07.271"},{"key":"e_1_2_12_3_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2015.0297"},{"key":"e_1_2_12_4_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jacr.2017.01.046"},{"key":"e_1_2_12_5_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2020.0578"},{"key":"e_1_2_12_6_1","doi-asserted-by":"publisher","DOI":"10.1159\/000478927"},{"key":"e_1_2_12_7_1","doi-asserted-by":"publisher","DOI":"10.1007\/s00330-021-08450-3"},{"key":"e_1_2_12_8_1","doi-asserted-by":"publisher","DOI":"10.3348\/kjr.2023.0461"},{"key":"e_1_2_12_9_1","doi-asserted-by":"publisher","DOI":"10.1109\/TMI.2024.3372602"},{"key":"e_1_2_12_10_1","doi-asserted-by":"publisher","DOI":"10.1148\/radiol.230949"},{"key":"e_1_2_12_11_1","doi-asserted-by":"publisher","DOI":"10.1002\/jum.16461"},{"key":"e_1_2_12_12_1","doi-asserted-by":"publisher","DOI":"10.4103\/jcrt.JCRT_913_19"},{"key":"e_1_2_12_13_1","doi-asserted-by":"publisher","DOI":"10.3233\/CH-190750"},{"key":"e_1_2_12_14_1","doi-asserted-by":"publisher","DOI":"10.1186\/s12880-023-00966-y"},{"key":"e_1_2_12_15_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1349-7006.2009.01250.x"},{"key":"e_1_2_12_16_1","doi-asserted-by":"publisher","DOI":"10.1159\/000452971"},{"key":"e_1_2_12_17_1","doi-asserted-by":"publisher","DOI":"10.1089\/thy.2009.0017"},{"key":"e_1_2_12_18_1","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21207718"},{"key":"e_1_2_12_19_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-13089-5"},{"key":"e_1_2_12_20_1","doi-asserted-by":"publisher","DOI":"10.1245\/s10434-022-11401-x"},{"key":"e_1_2_12_21_1","doi-asserted-by":"publisher","DOI":"10.11152\/mu-1422"}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71190","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T10:31:35Z","timestamp":1761129095000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71190"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8,29]]},"references-count":20,"journal-issue":{"issue":"17","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cam4.71190"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71190","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,8,29]]},"assertion":[{"value":"2025-05-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication 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