{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T23:46:01Z","timestamp":1761176761322,"version":"build-2065373602"},"reference-count":14,"publisher":"Wiley","issue":"17","license":[{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":1,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000348","name":"Calouste Gulbenkian Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>A Radiotherapy Service (RS) started working in the Maputo Central Hospital (MCH), Mozambique, in August 2019. Here we describe its first 5\u2009years of activity.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A total of 810 patients who underwent external radiotherapy between August 2019 and December 2023 were considered for the analysis. Sociodemographic and clinical data were retrieved from the RS database, and the MCH Cancer Registry was used to obtain cancer incidence data.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      There was an increase in newly admitted patients each year, except in 2023 (161 in 2020, 188 in 2021, 238 in 2022, and 185 in 2023). Patients admitted in 2019 were more likely to be from Maputo city and to receive palliative radiotherapy. The proportion of patients starting radiotherapy within 12, 24, 36, and 48\u2009months after diagnosis was 38.8%, 78.1%, 91.7%, and 96.6%, respectively. There was an increasing trend (\n                      <jats:italic>p<\/jats:italic>\n                      for trend &lt;\u20090.001) in the proportion of patients admitted with cervical cancer over time (from 34.2% in 2019 to 46.0% in 2023). Differences in radiotherapy initiation within 12\u2009months were observed according to treatment intent (42.6% for palliative vs. 36.9% for curative;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.014) and cancer site (64.5% for rectal\/anal cancer vs. 34.8%, 29.5%, and 37.0% for cervical, breast and prostate cancer patients, respectively;\n                      <jats:italic>p<\/jats:italic>\n                      \u2009&lt;\u20090.001).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>The RS\u2010MCH improved access to radiotherapy for cancer patients, particularly those with cervical and breast cancers. Patients undergoing palliative treatment and those with anal\/rectal cancers started radiotherapy earlier. Further research is needed to evaluate the impact of radiotherapy on mortality, survival, and in patient\u2010centered outcomes.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71199","type":"journal-article","created":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T10:55:45Z","timestamp":1756810545000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["External Radiotherapy in Mozambique: Report of the First Five Years of Activity of the Radiotherapy Service of the Maputo Central Hospital"],"prefix":"10.1002","volume":"14","author":[{"given":"Filipa","family":"Fontes","sequence":"first","affiliation":[{"name":"Abordagem de Les\u00f5es Pr\u00e9\u2010Cancerosas e Cancro Precoce \u2013 Centro de Investiga\u00e7\u00e3o (CI\u2010IPOP), Instituto Portugu\u00eas de Oncologia do Porto (IPO\u2010Porto) &amp; Porto Comprehensive Cancer Center (Porto.CCC) &amp; RISE@CI\u2010IPOP (Rede de Investiga\u00e7\u00e3o Em Sa\u00fade)  Porto Portugal"},{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina Universidade do Porto  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alberto Gudo","family":"Morais","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radioterapia, Hospital Central de Maputo  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joaquina","family":"Nhampule","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radioterapia, Hospital Central de Maputo  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sara","family":"Navarro","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radioterapia, Hospital Central de Maputo  Maputo Mozambique"},{"name":"Departament of Clinical Training &amp; Education Mercurius Health S.A. Taguspark, N\u00facleo Central Expans\u00e3o  Porto Salvo Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Narciso","family":"Sitoe","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radioterapia, Hospital Central de Maputo  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonel","family":"Amisse","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Radioterapia, Hospital Central de Maputo  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Satish","family":"Tulsid\u00e1s","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Oncologia M\u00e9dica Hospital Central de Maputo  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesaltina","family":"Lorenzoni","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Anatomia Patol\u00f3gica Hospital Central de Maputo  Maputo Mozambique"},{"name":"Departamento de Patologia, Faculdade de Medicina Universidade Eduardo Mondlane  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carla","family":"Carrilho","sequence":"additional","affiliation":[{"name":"Servi\u00e7o de Anatomia Patol\u00f3gica Hospital Central de Maputo  Maputo Mozambique"},{"name":"Departamento de Patologia, Faculdade de Medicina Universidade Eduardo Mondlane  Maputo Mozambique"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nuno","family":"Lunet","sequence":"additional","affiliation":[{"name":"Departamento de Ci\u00eancias da Sa\u00fade P\u00fablica e Forenses e Educa\u00e7\u00e3o M\u00e9dica, Faculdade de Medicina Universidade do Porto  Porto Portugal"},{"name":"EPIUnit Instituto de Sa\u00fade P\u00fablica da Universidade do Porto &amp; Laborat\u00f3rio Para a Investiga\u00e7\u00e3o Integrativa e Translacional Em Sa\u00fade Populacional (ITR)  Porto Portugal"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2025,9,2]]},"reference":[{"volume-title":"The Cancer Atlas","year":"2019","key":"e_1_2_9_2_1"},{"volume-title":"WHO List of Priority Medical Devices for Cancer Management","year":"2017","author":"World Health Organization","key":"e_1_2_9_3_1"},{"key":"e_1_2_9_4_1","unstructured":"J.Ferlay M.Ervik andF.Lam \u201cGlobal Cancer Observatory: Cancer Tomorrow \u201d(2020) International Agency for Research on Cancer."},{"key":"e_1_2_9_5_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470-2045(21)00351-X"},{"key":"e_1_2_9_6_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15041163"},{"volume-title":"Cancer Registration: Principles and Methods","year":"1991","author":"Jensen O. 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