{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T19:40:02Z","timestamp":1740166802864,"version":"3.37.3"},"reference-count":36,"publisher":"Wiley","issue":"7","license":[{"start":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T00:00:00Z","timestamp":1460592000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Science Foundation for Distinguished Young Scholars of China","award":["81402724","81225020"],"award-info":[{"award-number":["81402724","81225020"]}]},{"DOI":"10.13039\/501100013335","name":"National Key Basic Research Program For Youth","doi-asserted-by":"crossref","award":["2013CB911400"],"award-info":[{"award-number":["2013CB911400"]}],"id":[{"id":"10.13039\/501100013335","id-type":"DOI","asserted-by":"crossref"}]},{"name":"National Program for Support of Top-notch Young Professionals"},{"name":"National Major S&T Projects","award":["2009ZX10004-904","2011ZX10004-902","2013ZX10004-905"],"award-info":[{"award-number":["2009ZX10004-904","2011ZX10004-902","2013ZX10004-905"]}]},{"name":"Foundation for the Program for New Century Excellent Talents in University","award":["NCET-10-0178"],"award-info":[{"award-number":["NCET-10-0178"]}]},{"name":"Foundation for the Author of National Excellent Doctoral Dissertation","award":["201081"],"award-info":[{"award-number":["201081"]}]},{"name":"Foundation of Jiangsu Province for Distinguished Young Scholars","award":["BK2012042"],"award-info":[{"award-number":["BK2012042"]}]},{"name":"Outstanding Young Scholar Project of Fudan University"},{"name":"Jiangsu Province Clinical Science and Technology Projects","award":["BL2012008"],"award-info":[{"award-number":["BL2012008"]}]},{"name":"Priority Academic Program for the Development of Jiangsu Higher Education Institutions (Public Health and Preventive Medicine)"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2016,7]]},"abstract":"Abstract<\/jats:title>Previously we identified that HBV<\/jats:styled-content>(Hepatitis B virus) sequence variation, which may interact with host human leukocyte antigen (HLA<\/jats:styled-content><\/jats:italic>) genetic variation, could influence host risk of hepatocellular carcinoma (HCC<\/jats:styled-content>). More HBV<\/jats:styled-content>\u2010host interactions need to be identified. Protein tyrosine phosphatase nonreceptor type 12 (PTPN<\/jats:styled-content>12), serves as an antagonist to tyrosine kinase signaling, may play integral roles in immune response against HBV<\/jats:styled-content> infection and the development of HCC<\/jats:styled-content>. Rs11485985 was an expression quantitative trait loci (eQTL<\/jats:styled-content>) for PTPN<\/jats:styled-content>12<\/jats:italic> by bioinformatics analyses. In this study, we genotyped the PTPN<\/jats:styled-content>12 <\/jats:italic>eQTL<\/jats:styled-content> and sequenced the HBV<\/jats:styled-content> region EnhII<\/jats:styled-content>\/BCP<\/jats:styled-content>\/PC<\/jats:styled-content> in a case\u2013control cohort including 1507 HBV<\/jats:styled-content>\u2010related HCC<\/jats:styled-content> cases and 1560 HBV<\/jats:styled-content> persistent carriers as controls. The variant genotype GG<\/jats:styled-content> of rs11489585 increased HCC<\/jats:styled-content> risk compared to the HBV<\/jats:styled-content> persistent carriers (adjusted OR<\/jats:styled-content>\u00a0=\u00a02.03, 95% confidence interval [CI<\/jats:styled-content>s]\u00a0=\u00a01.30\u20133.18). We also detected borderline significant associations of PTPN<\/jats:styled-content>12 <\/jats:italic>eQTL<\/jats:styled-content> rs11489585 with HBV<\/jats:styled-content> mutations (P<\/jats:italic>\u00a0=\u00a00.05 for G1799C). Taken together, PTPN<\/jats:styled-content>12<\/jats:italic> may influence HCC<\/jats:styled-content> risk accompanied by HBV<\/jats:styled-content> mutations.<\/jats:p>","DOI":"10.1002\/cam4.712","type":"journal-article","created":{"date-parts":[[2016,4,14]],"date-time":"2016-04-14T06:08:48Z","timestamp":1460614128000},"page":"1687-1693","update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Hepatitis B virus mutations, expression quantitative trait loci for PTPN<\/scp>12, and their interactions in hepatocellular carcinoma"],"prefix":"10.1002","volume":"5","author":[{"given":"Ci","family":"Song","sequence":"first","affiliation":[{"name":"Department of Epidemiology Collaborative Innovation Center For Cancer Personalized Medicine School of Public Health Nanjing Medical University Nanjing 211166 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center of Cancer Medicine Nanjing Medical University Nanjing 211166 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yao","family":"Liu","sequence":"additional","affiliation":[{"name":"Pathology Center and Department of Pathology Soochow University Suzhou China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lu","family":"Xu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Collaborative Innovation Center For Cancer Personalized Medicine School of Public Health Nanjing Medical University Nanjing 211166 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan","family":"Wen","sequence":"additional","affiliation":[{"name":"Nanjing Maternity and Child Health Care Institute Nanjing Maternity and Child Health Care Hospital Affiliated with Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deke","family":"Jiang","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Genetic Engineering Collaborative Innovation Center for Genetics and Development School of Life Sciences Fudan University Shanghai China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianguo","family":"Chen","sequence":"additional","affiliation":[{"name":"Qidong Liver Cancer Institute Qidong China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiangjun","family":"Zhai","sequence":"additional","affiliation":[{"name":"Department of Infection Diseases Jiangsu Province Center for Disease Prevention and Control Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhibin","family":"Hu","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Collaborative Innovation Center For Cancer Personalized Medicine School of Public Health Nanjing Medical University Nanjing 211166 China"},{"name":"Jiangsu Key Lab of Cancer Biomarkers Prevention and Treatment Collaborative Innovation Center of Cancer Medicine Nanjing Medical University Nanjing 211166 China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Liu","sequence":"additional","affiliation":[{"name":"Digestive Endoscopy Center the First Affiliated Hospital of Nanjing Medical University Nanjing China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jibin","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Hepatobiliary Surgery Nantong Tumor Hospital Nantong China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"311","published-online":{"date-parts":[[2016,4,14]]},"reference":[{"key":"e_1_2_7_2_1","doi-asserted-by":"publisher","DOI":"10.3322\/caac.20107"},{"key":"e_1_2_7_3_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v21.i37.10584"},{"key":"e_1_2_7_4_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2005.00584.x"},{"key":"e_1_2_7_5_1","doi-asserted-by":"publisher","DOI":"10.1128\/JVI.02556-07"},{"key":"e_1_2_7_6_1","doi-asserted-by":"publisher","DOI":"10.3201\/eid1411.080437"},{"key":"e_1_2_7_7_1","doi-asserted-by":"publisher","DOI":"10.1111\/j.1365-2893.2004.00521.x"},{"key":"e_1_2_7_8_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.2007.13.2043"},{"key":"e_1_2_7_9_1","doi-asserted-by":"publisher","DOI":"10.1001\/jama.295.1.65"},{"key":"e_1_2_7_10_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa013215"},{"key":"e_1_2_7_11_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.virusres.2007.02.021"},{"key":"e_1_2_7_12_1","doi-asserted-by":"publisher","DOI":"10.1155\/2011\/870459"},{"key":"e_1_2_7_13_1","doi-asserted-by":"publisher","DOI":"10.1128\/MCB.01369-13"},{"key":"e_1_2_7_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1473-3099(07)70289-X"},{"key":"e_1_2_7_15_1","doi-asserted-by":"publisher","DOI":"10.1139\/o99-064"},{"key":"e_1_2_7_16_1","doi-asserted-by":"publisher","DOI":"10.1152\/ajpcell.00148.2010"},{"key":"e_1_2_7_17_1","doi-asserted-by":"publisher","DOI":"10.1021\/ac0348625"},{"key":"e_1_2_7_18_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.cell.2011.02.003"},{"key":"e_1_2_7_19_1","doi-asserted-by":"publisher","DOI":"10.1038\/ng2142"},{"key":"e_1_2_7_20_1","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pgen.1000214"},{"key":"e_1_2_7_21_1","doi-asserted-by":"publisher","DOI":"10.1038\/srep16489"},{"key":"e_1_2_7_22_1","doi-asserted-by":"publisher","DOI":"10.1002\/hep.24799"},{"key":"e_1_2_7_23_1","doi-asserted-by":"publisher","DOI":"10.1158\/1055-9965.EPI-09-1001"},{"key":"e_1_2_7_24_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jhep.2008.06.026"},{"key":"e_1_2_7_25_1","doi-asserted-by":"publisher","DOI":"10.3748\/wjg.v17.i38.4258"},{"key":"e_1_2_7_26_1","first-page":"86","article-title":"Genotypes, 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