{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,17]],"date-time":"2026-07-17T16:29:28Z","timestamp":1784305768485,"version":"3.55.0"},"reference-count":32,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T00:00:00Z","timestamp":1758499200000},"content-version":"vor","delay-in-days":21,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82303656"],"award-info":[{"award-number":["82303656"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Cross\u2010resistance is observed between platinum and Poly (ADP\u2010ribose) polymerase inhibitors (PARPi). We aim to propose the definition of PARPi resistance and demonstrate the best therapeutic strategy for patients with PARPi resistance.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective analysis was performed on patients diagnosed with epithelial ovarian cancer from October 2015 to November 2022. Patients were treated with PARPi for more than 6\u2009months and received chemotherapy after progression.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Totally, 41 patients were enrolled, with 21 receiving PARPi for 6 to 12\u2009months and 20 for more than 12\u2009months. The median duration of PARPi was 12\u2009months, and the median time to second progression (TTSP) was 3.45\u2009months (range, 1.0\u201320.2\u2009months). The Kaplan\u2013Meier and Cox analysis revealed a significantly shorter TTSP for patients who received PARPi for more than 12\u2009months compared to those for 6 to 12\u2009months. After PARPi resistance, 34 (82.9%) received platinum\u2010based chemotherapy, with an overall response rate (ORR) of 26.5% (9\/34). Seven patients (17.1%) received arsenic trioxide (ATO)\u2010based chemotherapy, with an ORR of 57.1% (4\/7). During subsequent chemotherapy, 12\/34 patients switched to ATO\u2010based chemotherapy due to progression, of which five cases were evaluated as effective (41.7%).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>PARPi resistance has a negative impact on the subsequent chemotherapy. The progression of the disease beyond 6 to 12\u2009months should be considered as acquired resistance. Non\u2010platinum chemotherapy, such as ATO\u2010based combined sequential chemotherapy, may emerge as the preferred option for patients with PARPi resistance.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71208","type":"journal-article","created":{"date-parts":[[2025,9,22]],"date-time":"2025-09-22T12:15:07Z","timestamp":1758543307000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Sensitivity of Platinum\u2010Based Chemotherapy and Efficacy of Arsenic Trioxide\u2010Based Non\u2010Platinum Chemotherapy Following the Progression of\n                    <scp>PARPi<\/scp>\n                    Maintenance Therapy: A Real\u2010World Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6584-623X","authenticated-orcid":false,"given":"Rui","family":"Gou","sequence":"first","affiliation":[{"name":"Department of Obstetrics and Gynecology Peking University People's 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