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Associations between single nucleotide polymorphism (SNP) genotypes and neurotoxicities with significant inter\u2010population disparities were calculated to identify independent, functional variants with population allele frequency differentiation associated with toxicities.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Following four cycles of cisplatin\u2010based chemotherapy, African ancestry survivors were significantly more likely to have neuropathy and vertigo versus European and Asian\u2010axis ancestry survivors, although Asian axis survivors were significantly younger at evaluation than other ancestries. Following filtering for population allele frequency differentiation, functional relevance, and independence, 19,992 SNPs were tested for association with toxicities. Although none passed the Bonferroni threshold, two and four SNPs were associated with neuropathy and vertigo, respectively, at suggestively significant\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20091.0 \u00d7\u200910\n                      <jats:sup>\u22124<\/jats:sup>\n                      . For neuropathy, rs34904346 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20092.0 \u00d7\u200910\n                      <jats:sup>\u22125<\/jats:sup>\n                      ) was an expression quantitative trait locus (eQTL) for RNF24 in nerve tissue, with three other RNF24 eQTLs associated with neuropathy (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.01). For vertigo, rs3777909 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20093.1 \u00d7\u200910\n                      <jats:sup>\u22125<\/jats:sup>\n                      ) was an eQTL for MFSD4B in nerve and REV3L in brain tissue, along with three other eQTLs for MFSD4B and four for REV3L associated with vertigo (\n                      <jats:italic>p<\/jats:italic>\n                      &lt;\u20090.05). In silico, higher MFSD4B and REV3L expression in cancer cell lines were associated with significantly greater cisplatin sensitivity.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>African ancestry was associated with increased cisplatin\u2010induced peripheral sensory neuropathy and vertigo versus European ancestry. Population allele frequency differences and expression levels of RNF24, MFSD4B, and REV3L were potentially implicated.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71218","type":"journal-article","created":{"date-parts":[[2025,9,6]],"date-time":"2025-09-06T05:52:27Z","timestamp":1757137947000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Impact of Population Pharmacogenomics on Cisplatin\u2010Induced Neurotoxicities in Testicular Cancer Survivors"],"prefix":"10.1002","volume":"14","author":[{"given":"Swetha","family":"Nakshatri","sequence":"first","affiliation":[{"name":"Department of Medicine University of Chicago  Chicago Illinois USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0235-8519","authenticated-orcid":false,"suffix":"Jr","given":"Paul C.","family":"Dinh","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Einhorn","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Indiana University  Indianapolis Indiana USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Darren R.","family":"Feldman","sequence":"additional","affiliation":[{"name":"Department of Medical Oncology Memorial Sloan\u2010Kettering Cancer Center  New York New York USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Department of Surgical Oncology Princess Margaret Cancer Centre  Toronto Ontario Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David J.","family":"Vaughn","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Pennsylvania  Philadelphia Pennsylvania USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunkit","family":"Fung","sequence":"additional","affiliation":[{"name":"J.P. 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