{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,5]],"date-time":"2026-08-05T01:31:23Z","timestamp":1785893483764,"version":"3.56.0"},"reference-count":34,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Inotuzumab Ozogamicin (InO) has shown efficacy in relapsed\/refractory acute lymphoblastic leukemia (R\/R ALL), but evidence from Latin America is scarce. We evaluated the outcomes of Chilean patients treated with InO in public and private health centers.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>We retrospectively analyzed 35 patients with R\/R ALL (median age 33\u2009years; 54% male). Twenty percent had BCR::ABL\u2010positive ALL, 78% expressed CD22, and 91% expressed CD19. Response rates, measurable residual disease (MRD), survival outcomes, and treatment\u2010related toxicities were assessed. Multivariate analyses explored prognostic factors.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Complete remission or remission with incomplete recovery (CR\/CRi) was achieved in 74% of patients. Among those evaluated, 82% reached MRD &lt;\u20090.01%. Patients undergoing allogeneic hematopoietic stem cell transplantation (Allo\u2010HSCT) after InO had superior overall survival (OS) compared with those who did not (24.2 vs. 5.2 months). Median progression\u2010free survival (PFS) was 6.9 months and median OS was 8.8 months. Sinusoidal obstruction syndrome occurred in 14% of patients but was generally mild. Multivariate analysis identified comorbidities and high blast counts as adverse prognostic factors, whereas MRD negativity and subsequent Allo\u2010HSCT were associated with improved outcomes.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>InO demonstrated high remission and MRD negativity rates in Chilean patients with R\/R ALL, with OS and PFS comparable to existing research. Although SOS incidence was higher, it was generally mild. Achieving MRD negativity and proceeding to Allo\u2010HSCT provided the greatest survival benefit. Study limitations include short follow\u2010up and limited data.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71230","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T14:22:08Z","timestamp":1757686928000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Real\u2010World Data on Inotuzumab Ozogamicin for Adult Patients With Relapsed\/Refractory Acute Lymphoblastic Leukemia: A GRELAL\u2010Chile Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9291-646X","authenticated-orcid":false,"given":"Marcela","family":"Espinoza","sequence":"first","affiliation":[{"name":"Cl\u00ednica D\u00e1vila  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5939-3035","authenticated-orcid":false,"given":"Jorge","family":"Rojas\u2010Vallejos","sequence":"additional","affiliation":[{"name":"Universidad Andres Bello  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3186-6403","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hospital Barros Luco Trudeau  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gonzalo","family":"Guerrero","sequence":"additional","affiliation":[{"name":"Cl\u00ednica RedSalud Vitacura  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"L\u00f3pez","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Alemana  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia","family":"Aranguiz","sequence":"additional","affiliation":[{"name":"Cl\u00ednica Alemana  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0776-7402","authenticated-orcid":false,"given":"Guillermo","family":"Conte","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico de la Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco","family":"Samaniego","sequence":"additional","affiliation":[{"name":"Hospital Cl\u00ednico de la Universidad de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0006-2075-8910","authenticated-orcid":false,"given":"Nicol\u00e1s","family":"Quinteros","sequence":"additional","affiliation":[{"name":"Departamento Medicina Interna Sede Centro Universidad de Chile Hospital Cl\u00ednico San Borja de Arriar\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Astete","sequence":"additional","affiliation":[{"name":"Departamento Medicina Interna Sede Centro Universidad de Chile Hospital Cl\u00ednico San Borja de Arriar\u00e1n  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Carcamo","sequence":"additional","affiliation":[{"name":"Hospital Gustavo Fricke  Vi\u00f1a del Mar Chile"},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez Instituto Oncol\u00f3gico  Providencia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Constanza","family":"Flores","sequence":"additional","affiliation":[{"name":"Hospital San Juan de Dios de La Serena  La Serena Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ximena","family":"Huerta","sequence":"additional","affiliation":[{"name":"Hospital Carlos Van Buren  Valpara\u00edso Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-7047-4994","authenticated-orcid":false,"given":"Mauricio","family":"Chand\u00eda","sequence":"additional","affiliation":[{"name":"Hospital Guillermo Gran Benavente  Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-3101-9846","authenticated-orcid":false,"given":"Jorge","family":"Valenzuela","sequence":"additional","affiliation":[{"name":"Universidad de Concepci\u00f3n  Concepci\u00f3n Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2044-9548","authenticated-orcid":false,"given":"Marcelo","family":"Navarrete","sequence":"additional","affiliation":[{"name":"Universidad de Magallanes  Punta Arenas Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9920-9861","authenticated-orcid":false,"given":"Yorman","family":"Flores","sequence":"additional","affiliation":[{"name":"Pontificia Universidad Cat\u00f3lica de Chile  Santiago Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Agatha","family":"Larrazabal","sequence":"additional","affiliation":[{"name":"Hematology Resident Universidad de los Andes  Santiago Chile"},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez Instituto Oncol\u00f3gico  Providencia Chile"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edgar","family":"Zapata","sequence":"additional","affiliation":[{"name":"Hematology Resident Universidad de los Andes  Santiago Chile"},{"name":"Fundaci\u00f3n Arturo L\u00f3pez P\u00e9rez Instituto Oncol\u00f3gico  Providencia 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Ministerio de Salud Gobierno de Chile. Acta N\u00b0 5\/19 https:\/\/www.ispch.cl\/sites\/default\/files\/documento\/2019\/08\/acta_5_comision_evaluadora_2019.pdf."},{"key":"e_1_2_9_14_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbmt.2019.04.020"},{"key":"e_1_2_9_15_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1509277"},{"key":"e_1_2_9_16_1","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15133346"},{"key":"e_1_2_9_17_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2017.2380"},{"key":"e_1_2_9_18_1","doi-asserted-by":"publisher","DOI":"10.1111\/ejh.14031"},{"key":"e_1_2_9_19_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.clml.2020.03.004"},{"key":"e_1_2_9_20_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709919"},{"key":"e_1_2_9_21_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1709866"},{"key":"e_1_2_9_22_1","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa1609783"},{"key":"e_1_2_9_23_1","doi-asserted-by":"publisher","DOI":"10.1182\/blood\u20102017\u201008\u2010798322"},{"key":"e_1_2_9_24_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.33321"},{"key":"e_1_2_9_25_1","doi-asserted-by":"publisher","DOI":"10.1016\/j.leukres.2019.106283"},{"key":"e_1_2_9_26_1","doi-asserted-by":"publisher","DOI":"10.1002\/cncr.30264"},{"key":"e_1_2_9_27_1","doi-asserted-by":"publisher","DOI":"10.1002\/ajh.27227"},{"key":"e_1_2_9_28_1","doi-asserted-by":"publisher","DOI":"10.1007\/s40273\u2010019\u201000812\u20106"},{"key":"e_1_2_9_29_1","doi-asserted-by":"publisher","DOI":"10.57264\/cer\u20102023\u20100142"},{"key":"e_1_2_9_30_1","doi-asserted-by":"publisher","DOI":"10.1016\/S1470\u20102045(18)30011\u20101"},{"key":"e_1_2_9_31_1","doi-asserted-by":"publisher","DOI":"10.1016\/S2352\u20103026(23)00073\u2010X"},{"key":"e_1_2_9_32_1","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.24.00490"},{"key":"e_1_2_9_33_1","doi-asserted-by":"publisher","DOI":"10.1001\/jamaoncol.2024.0967"},{"key":"e_1_2_9_34_1","doi-asserted-by":"publisher","DOI":"10.1182\/bloodadvances.2023011514"},{"key":"e_1_2_9_35_1","doi-asserted-by":"publisher","DOI":"10.1080\/17474086.2025.2450223"}],"updated-by":[{"DOI":"10.1002\/cam4.71385","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2025,12,16]],"date-time":"2025-12-16T00:00:00Z","timestamp":1765843200000}}],"container-title":["Cancer Medicine"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/pdf\/10.1002\/cam4.71230","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:27:52Z","timestamp":1766219272000},"score":1,"resource":{"primary":{"URL":"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/cam4.71230"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,9]]},"references-count":34,"journal-issue":{"issue":"18","published-print":{"date-parts":[[2025,9]]}},"alternative-id":["10.1002\/cam4.71230"],"URL":"https:\/\/doi.org\/10.1002\/cam4.71230","archive":["Portico"],"relation":{},"ISSN":["2045-7634","2045-7634"],"issn-type":[{"value":"2045-7634","type":"print"},{"value":"2045-7634","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,9]]},"assertion":[{"value":"2025-02-12","order":0,"name":"received","label":"Received","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-08-28","order":2,"name":"accepted","label":"Accepted","group":{"name":"publication_history","label":"Publication History"}},{"value":"2025-09-12","order":3,"name":"published","label":"Published","group":{"name":"publication_history","label":"Publication History"}}],"article-number":"e71230"}}