{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,20]],"date-time":"2025-12-20T08:30:41Z","timestamp":1766219441920,"version":"3.48.0"},"reference-count":30,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T00:00:00Z","timestamp":1757635200000},"content-version":"vor","delay-in-days":11,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Hereditary hematological malignancy syndromes (HHMS) are more common than previously thought, and identification of an HHMS syndrome can inform the choice of treatments, transplant, and testing of other family members. Genetic testing guidelines for hematological malignancy have broadened; however, there remain a multitude of barriers and complexities with germline genetic testing for these patients. Here, we describe a process for the evaluation and testing of patients for HHMS as well as our respective findings.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Adult patients with a new diagnosis or history of myeloid malignancy and referred for genetic counseling from 2020 to 2023 within a single institution were reviewed. Descriptive statistics were performed, and frequency data was gathered for relevant patients.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>A total of forty\u2010nine patients were evaluated by a genetic counselor based on their myeloid malignancy; forty\u2010three patients underwent genetic testing. Genetic testing revealed an HHMS for six patients, with two additional patients found to have abnormalities on ancillary testing that could not be genetically characterized. Thirty\u2010five patients met NCCN age\u2010based criteria for genetic testing; however, this was not mutually exclusive with those diagnosed with HHMS. Inpatient genetic counseling had a median timeline of 53\u2009days from referral to result (range: 32\u201356.75\u2009days). Outpatient genetic counseling had a median timeline of 96\u2009days from referral to result (range: 64\u2013144\u2009days).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusion<\/jats:title>\n                    <jats:p>Our proposed process demonstrates an efficient structure for patients with hematological malignancy while supporting the importance of the genetic counselor within the malignant hematology and stem cell transplant teams.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71240","type":"journal-article","created":{"date-parts":[[2025,9,12]],"date-time":"2025-09-12T08:12:28Z","timestamp":1757664748000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Implementing a Genetic Counselor\u2010Led Model for Hereditary Myeloid Malignancies: A Real\u2010World Study"],"prefix":"10.1002","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0009-0007-5166-2273","authenticated-orcid":false,"given":"Madeline","family":"VanDerGraaf","sequence":"first","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa Healthcare  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Georgianne","family":"Younger","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics and Genomics, Stead Family Department of Pediatrics University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyle","family":"Dillahunt","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics and Genomics, Stead Family Department of Pediatrics University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jennifer","family":"Smith","sequence":"additional","affiliation":[{"name":"Franciscan Health Indianapolis  Indianapolis Indiana USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Athena","family":"Puski","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa Healthcare  Iowa City Iowa USA"},{"name":"Ambry Genetics  Aliso Viejo California USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicole","family":"Blum","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa Healthcare  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hailey","family":"Manwiller","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa Healthcare  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jaime","family":"Nagy","sequence":"additional","affiliation":[{"name":"Division of Medical Genetics and Genomics, Stead Family Department of Pediatrics University of Iowa  Iowa City Iowa USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Grerk","family":"Sutamtewagul","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kittika","family":"Poonsombudlert","sequence":"additional","affiliation":[{"name":"Division of Hematology, Oncology, and Blood and Marrow Transplantation, Department of Internal Medicine, Carver College of Medicine University of Iowa  Iowa City Iowa USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Moon Ley","family":"Tung","sequence":"additional","affiliation":[{"name":"Holden Comprehensive Cancer Center University of Iowa Healthcare  Iowa City Iowa USA"},{"name":"Division of Medical Genetics and Genomics, Stead Family Department of Pediatrics University of Iowa  Iowa City Iowa USA"},{"name":"Carver College of Medicine University of Iowa  Iowa City Iowa 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