{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T22:38:40Z","timestamp":1772923120381,"version":"3.50.1"},"reference-count":59,"publisher":"Wiley","issue":"18","license":[{"start":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T00:00:00Z","timestamp":1758067200000},"content-version":"vor","delay-in-days":16,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100017686","name":"Fujian Provincial Health Technology Project","doi-asserted-by":"publisher","award":["2024QNA055"],"award-info":[{"award-number":["2024QNA055"]}],"id":[{"id":"10.13039\/501100017686","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011083"],"award-info":[{"award-number":["2024J011083"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2024J011094"],"award-info":[{"award-number":["2024J011094"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003392","name":"Natural Science Foundation of Fujian Province","doi-asserted-by":"publisher","award":["2025J011171"],"award-info":[{"award-number":["2025J011171"]}],"id":[{"id":"10.13039\/501100003392","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,9]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Total gastrectomy (TG) is the predominant approach for proximal gastric cancer; however, it frequently leads to various postoperative nutritional and metabolic disorders. Recently, double\u2010tract reconstruction (DTR) following proximal gastrectomy (PG) has been developed to preserve gastric function and reduce postoperative reflux esophagitis. This study aimed to compare the outcomes of PG\u2010DTR with those of TG in patients with proximal gastric cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Patients with clinically staged cT1 to cT2 proximal gastric cancer who underwent either PG\u2010DTR or TG with Roux\u2010en\u2010Y reconstruction (TG\u2010RY) were enrolled. Propensity score matching (PSM) was applied to reduce confounding bias. Surgical outcomes, nutritional status, reflux esophagitis, and prognosis were prospectively analyzed. Quality of life (QOL) was assessed at 3, 6, and 12\u2009months postoperatively using the Postgastrectomy Syndrome Assessment Scale\u201045 (PGSAS\u201045).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>After PSM, 93 patients were included in each group (PG\u2010DTR and TG\u2010RY). The PG\u2010DTR group had fewer retrieved lymph nodes than the TG\u2010RY group. No significant differences were observed between the groups in operative time, blood loss, postoperative complications, length of hospital stay, reflux esophagitis, overall survival (OS), or disease\u2010free survival (DFS). Female sex, preoperative BMI, TG\u2010RY procedure, and severe postoperative complications (POCs) were identified as independent risk factors for malnutrition at 3\u2009months postgastrectomy. Postoperatively, the TG\u2010RY group exhibited significantly lower levels of hemoglobin, total protein, and albumin than the PG\u2010DTR group. No differences were observed in postoperative QOL between the two groups, except for greater weight loss in the TG\u2010RY group.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Compared to TG\u2010RY, PG\u2010DTR was associated with improved postoperative nutritional status, including better body weight, hemoglobin, and albumin levels, in patients with early\u2010stage proximal gastric cancer. Additionally, PG\u2010DTR demonstrated comparable short\u2010term outcomes, prognosis, and postoperative QOL to TG\u2010RY, further supporting its viability as a surgical option.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71258","type":"journal-article","created":{"date-parts":[[2025,9,17]],"date-time":"2025-09-17T10:00:17Z","timestamp":1758103217000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Short\u2010 and Mid\u2010Term Outcomes of Proximal Gastrectomy With Double\u2010Tract Reconstruction Versus Total Gastrectomy in Early\u2010Stage Proximal Gastric Cancer"],"prefix":"10.1002","volume":"14","author":[{"given":"Ying","family":"Liu","sequence":"first","affiliation":[{"name":"Department of Gastric Surgery Clinical Oncology School of Fujian Medical University, Fujian Cancer Hospital  Fuzhou Fujian 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