{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,17]],"date-time":"2026-08-17T14:32:18Z","timestamp":1786977138103,"version":"build-2736575974"},"reference-count":49,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T00:00:00Z","timestamp":1759104000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["K24HL150476"],"award-info":[{"award-number":["K24HL150476"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K08CA252635"],"award-info":[{"award-number":["K08CA252635"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>Asian Americans (AAs) are a diverse population, and aggregation of AA health data in national reports conceals significant differences between AA subgroups. As hepatobiliary cancer rates increase globally, a greater understanding of hepatobiliary mortality among AA subgroups could motivate precision intervention and screening programs.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Using national mortality data from 2005 to 2020, we report age\u2010adjusted mortality rates, standardized mortality ratios, and annual percent change for hepatocellular carcinoma (HCC), nonspecified liver cancer (NOS), intrahepatic cholangiocarcinoma (ICC), extrahepatic cholangiocarcinoma (ECC), and gallbladder cancer (GBC) using national mortality data for the six largest AA subgroups (Asian Indian, Chinese, Filipino, Japanese, Korean, and Vietnamese) compared to non\u2010Hispanic White people (NHW).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>All AA subgroups (except Asian Indians) had significantly higher hepatobiliary cancer mortality than NHW people. Vietnamese people demonstrated the highest mortality from HCC (7.65 per 100,000) and nonspecified liver cancer (5.57 per 100,000), while Korean people had the highest mortality from the biliary tract cancers: ICC (3.10 per 100,000), GBC (0.72 per 100,000), and ECC (0.97 per 100,000). Notably, ICC mortality increased across the study period. Across all subgroups, male individuals had significantly higher hepatobiliary cancer mortality than female individuals, with differences being largest for HCC and nonspecified liver cancer.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Differences in mortality across hepatobiliary cancer types demonstrate the importance of analyzing subtypes separately. These differences also highlight the importance of developing ethnically targeted screening, prevention strategies, and treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71259","type":"journal-article","created":{"date-parts":[[2025,9,29]],"date-time":"2025-09-29T13:04:41Z","timestamp":1759151081000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Disaggregation of Hepatobiliary Cancer Mortality Among Asian Americans: Analysis of\n                    <scp>NVSS<\/scp>\n                    Mortality Data"],"prefix":"10.1002","volume":"14","author":[{"given":"Anna","family":"Park","sequence":"first","affiliation":[{"name":"School of Medicine Georgetown University  Washington DC USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew","family":"Vodinh\u2010Ho","sequence":"additional","affiliation":[{"name":"Department of Physics Princeton University  Princeton New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivory","family":"Rok","sequence":"additional","affiliation":[{"name":"Department of Medicine University of Nevada, Reno School of Medicine  Reno Nevada USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1348-5444","authenticated-orcid":false,"given":"Xinran","family":"Qi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology Johns Hopkins Bloomberg School of Public Health  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George A.","family":"Hung","sequence":"additional","affiliation":[{"name":"Department of Medicine Rutgers New Jersey Medical School  Newark New Jersey USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas","family":"Kikuta","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armaan","family":"Jamal","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Department of Medicine Johns Hopkins University School of Medicine  Baltimore Maryland USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gloria S.","family":"Kim","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Cardiovascular Medicine Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Latha P.","family":"Palaniappan","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Cardiovascular Medicine Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Malathi","family":"Srinivasan","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Primary Care and Population Health Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert J.","family":"Huang","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Gastroenterology and Hepatology Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0157-4754","authenticated-orcid":false,"given":"Adrian M.","family":"Bacong","sequence":"additional","affiliation":[{"name":"Center for Asian Health Research and Education Stanford University School of Medicine  Stanford California USA"},{"name":"Division of Cardiovascular Medicine Stanford University School of Medicine  Stanford California USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"311","published-online":{"date-parts":[[2025,9,29]]},"reference":[{"key":"e_1_2_11_2_1","unstructured":"A.Budiman N. 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