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MicroRNAs (miRNAs) are small, non\u2010coding RNA transcripts that play significant roles in cancer initiation and progression. In this study, we focused on the miR\u2010181 family members' influence on OSCC tumorigenesis and progression, focusing on their distinct biological functions and regulatory mechanisms in OSCC\u2010specific contexts. Attention was given to the potential of these transcripts as biomarkers, considering their differential expression in OSCC tissues and biofluids such as plasma, serum, and saliva. Alterations in salivary miR\u2010181 levels have been correlated with different stages of oral lesion progression, underscoring their utility as non\u2010invasive biomarkers for early detection and risk stratification. Moreover, we discuss the implications of miR\u2010181 family modulation on biological processes in preclinical OSCC studies, highlighting their involvement in cancer hallmarks, including invasion, migration, metastasis, radio\u2010 and chemotherapy resistance. These findings underscore the therapeutic and diagnostic potential of the miR\u2010181 family in OSCC management.<\/jats:p>","DOI":"10.1002\/cam4.71266","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T11:20:17Z","timestamp":1758885617000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Roles of\n                    <scp>miR<\/scp>\n                    \u2010181 Family Members in\n                    <scp>OSCC<\/scp>\n                    : Implications for Therapy and Diagnostics"],"prefix":"10.1002","volume":"14","author":[{"given":"Alexandra Iulia","family":"Aghiorghiesei","sequence":"first","affiliation":[{"name":"Department of Prosthodontics and Dental Materials Faculty of Dental Medicine, Iuliu Ha\u021bieganu University of Medicine and Pharmacy  Cluj\u2010Napoca 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