{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T02:28:10Z","timestamp":1789180090158,"version":"build-2803163510"},"reference-count":16,"publisher":"Wiley","issue":"19","license":[{"start":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T00:00:00Z","timestamp":1758844800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012166","name":"National Key Research and Development Program of China","doi-asserted-by":"publisher","award":["2023YFC2410203"],"award-info":[{"award-number":["2023YFC2410203"]}],"id":[{"id":"10.13039\/501100012166","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["onlinelibrary.wiley.com"],"crossmark-restriction":true},"short-container-title":["Cancer Medicine"],"published-print":{"date-parts":[[2025,10]]},"abstract":"<jats:title>ABSTRACT<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Background<\/jats:title>\n                    <jats:p>This study aims to investigate bilateral orbital development differences and influencing factors in retinoblastoma patients undergoing unilateral enucleation.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>A retrospective comparative analysis was performed on patients from Beijing Tongren Hospital (January 2011\u2013December 2020). Preoperative and 3\u2009months, 1\u2009year, 3\u2009years postoperative, and the final follow\u2010up imaging data were collected, with bilateral orbital volumes reconstructed using ITK\u2010SNAP software.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Thirty\u2010nine patients were followed for an average of 7.7\u2009\u00b1\u20092.45\u2009years. Average orbital volumes (mm\n                      <jats:sup>3<\/jats:sup>\n                      ) for the surgical and nonsurgical sides before surgery were 14,323.81\u2009\u00b1\u20094596.60 and 14,457.93\u2009\u00b1\u20094732.26 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.330). Postoperative volumes at 3\u2009months were 16,481.84\u2009\u00b1\u20094034.21 and 16,866.45\u2009\u00b1\u20093999.71 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.007). At 12\u2009months, volumes were 16,798.16\u2009\u00b1\u20093323.33 and 18,119.16\u2009\u00b1\u20093840.27 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). At 36\u2009months, volumes were 18,758.26\u2009\u00b1\u20092917.35 and 19,973.55\u2009\u00b1\u20093189.83 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). The last follow\u2010up volumes were 20,523.78\u2009\u00b1\u20093221.20 and 21,576.78\u2009\u00b1\u20093381.96 (\n                      <jats:italic>p<\/jats:italic>\n                      \u2009=\u20090.000). Bilateral volume differences were 2.28%, 7.29%, 6.08%, and 4.88% at 3\u2009months, 12\u2009months, 36\u2009months after operation, and final follow\u2010up. The growth trajectory on the surgical side demonstrated growth restrictions, accompanied by a shift in the growth peak. Factors affecting development included the age at the time of operation and the type of orbital implants.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Volumetric analysis revealed active orbital development between 3 and 12\u2009months post\u2010enucleation, followed by a significant plateau phase. The final orbital volume deficit in the surgical orbit stabilized at approximately 5% compared to the non\u2010operated orbit. Hydrogel implants demonstrated a trade\u2010off: potentially reduced volume deficit but higher complication risks.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1002\/cam4.71282","type":"journal-article","created":{"date-parts":[[2025,9,26]],"date-time":"2025-09-26T10:54:22Z","timestamp":1758884062000},"update-policy":"https:\/\/doi.org\/10.1002\/crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Long\u2010Term Observation of Orbital Development in Patients With Retinoblastoma Following Unilateral Enucleation"],"prefix":"10.1002","volume":"14","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feng","family":"Ke","sequence":"additional","affiliation":[{"name":"Shiyan Renmin Hospital  Shiyan China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Li","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tingting","family":"Ren","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Liu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fuxiao","family":"Luan","sequence":"additional","affiliation":[{"name":"Beijing Chaoyang Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liangyuan","family":"Xu","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8667-8645","authenticated-orcid":false,"given":"Jianmin","family":"Ma","sequence":"additional","affiliation":[{"name":"Beijing Tongren Hospital, Capital Medical University  Beijing 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